Cell ablation

Cell ablation (also known as tissue ablation) is a biotechnological tool for studying cell lineage and/or function and is a form of ablation. The process consists of selectively destroying one or multiple cells in a given organism by any chosen means. For example, a laser beam or a controllable gene promoter for a toxin gene can be used to destroy a selected amount of cells.^[1] Cell ablation can also be used as a tool to produce transgenic organisms lacking a cell type and as a cure for certain disorders such as cancer and leukemia. The term is not to be confused with genetic ablation: a method of modifying DNA in order to disrupt the production of a specific gene. As genetic ablation may lead to cell ablation, it can be used as a synonymous term at appropriate times.

↑ Michiko, Saito; et al. (1 August 2001). "Diphtheria toxin receptor mediated conditional and targeted cell ablation in transgenic mice". Nature Biotechnology. 19: 746–750. doi:10.1038/90795.

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[1] Michiko, Saito; et al. (1 August 2001). "Diphtheria toxin receptor mediated conditional and targeted cell ablation in transgenic mice". Nature Biotechnology. 19: 746–750. doi:10.1038/90795.