Cdc42 binding protein kinase beta

CDC42BPB
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3QFV, 3TKU, 4UAK, 4UAL
Identifiers
Aliases	CDC42BPB, MRCKB, CDC42 binding protein kinase beta
External IDs	MGI: 2136459 HomoloGene: 55945 GeneCards: CDC42BPB
Gene location (Human)
Chr.	Chromosome 14 (human)[1]
End	103,057,462 bp[1]
Gene location (Mouse)
Chr.	Chromosome 12 (mouse)[2]
End	111,377,718 bp[2]
Gene ontology
Molecular function	• transferase activity; • protein kinase activity; • nucleotide binding; • metal ion binding; • kinase activity; • protein serine/threonine kinase activity; • Rho GTPase binding; • ATP binding; • magnesium ion binding; • protein binding;
Cellular component	• cytoplasm; • membrane; • cell-cell junction; • plasma membrane; • cell junction; • cell leading edge; • actomyosin; • cytoskeleton; • extracellular exosome; • lamellipodium; • cell projection;
Biological process	• intracellular signal transduction; • phosphorylation; • actomyosin structure organization; • establishment or maintenance of cell polarity; • protein phosphorylation; • cytoskeleton organization; • cell migration; • signal transduction; • actin cytoskeleton organization; • actin cytoskeleton reorganization;
	Sources:Amigo / QuickGO
Orthologs
	9578
	217866
	ENSG00000198752
	ENSMUSG00000021279
	Q9Y5S2; Q86XZ8
	Q7TT50
	NM_006035
	NM_183016
	NP_006026; NP_006026.3
	NP_898837
	Wikidata
View/Edit Human	View/Edit Mouse

CDC42 binding protein kinase beta is a protein that in humans is encoded by the CDC42BPB gene. ^[5]

Function

This gene encodes a member of the serine/threonine protein kinase family. The encoded protein contains a Cdc42/Rac-binding p21 binding domain resembling that of PAK kinase. The kinase domain of this protein is most closely related to that of myotonic dystrophy kinase-related ROK. Studies of the similar gene in rat suggested that this kinase may act as a downstream effector of Cdc42 in cytoskeletal reorganization.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000198752 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000021279 - Ensembl, May 2017
↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
↑ "Entrez Gene: CDC42 binding protein kinase beta". Retrieved 2017-05-31.

Choi SH, Czifra G, Kedei N, Lewin NE, Lazar J, Pu Y, Marquez VE, Blumberg PM (2008). "Characterization of the interaction of phorbol esters with the C1 domain of MRCK (myotonic dystrophy kinase-related Cdc42 binding kinase) alpha/beta". J. Biol. Chem. 283 (16): 10543–9. doi:10.1074/jbc.M707463200. PMC 2447637. PMID 18263588.
Kim YJ, Kim NY, Lee MK, Choi HJ, Baek HJ, Nam CH (2010). "Overexpression and unique rearrangement of VH2 transcripts in immunoglobulin variable heavy chain genes in ankylosing spondylitis patients". Exp. Mol. Med. 42 (5): 319–26. doi:10.3858/emm.2010.42.5.030. PMC 2877252. PMID 20177145.
Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR (2010). "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score". Mol. Med. 16 (7–8): 247–53. doi:10.2119/molmed.2009.00159. PMC 2896464. PMID 20379614.
Huo L, Wen W, Wang R, Kam C, Xia J, Feng W, Zhang M (2011). "Cdc42-dependent formation of the ZO-1/MRCKβ complex at the leading edge controls cell migration". EMBO J. 30 (4): 665–78. doi:10.1038/emboj.2010.353. PMC 3041950. PMID 21240187.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000198752 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000021279 - Ensembl, May 2017

[3] "Human PubMed Reference:".

[4] "Mouse PubMed Reference:".

[entrez-5] "Entrez Gene: CDC42 binding protein kinase beta". Retrieved 2017-05-31.

Cdc42 binding protein kinase beta

Function

References

Further reading