Carbonic anhydrase 7

CA7
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesCA7, CAVII, carbonic anhydrase 7, CA-VII
External IDsMGI: 103100 HomoloGene: 55875 GeneCards: CA7
Gene location (Human)
Chr.Chromosome 16 (human)[1]
Band16q22.1Start66,844,379 bp[1]
End66,854,153 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

766

12354

Ensembl

ENSG00000168748

ENSMUSG00000031883

UniProt

P43166

Q9ERQ8

RefSeq (mRNA)

NM_001014435
NM_005182
NM_001365337

NM_001301164
NM_001301165
NM_053070

RefSeq (protein)

NP_001014435
NP_005173
NP_001352266

NP_001288093
NP_001288094
NP_444300

Location (UCSC)Chr 16: 66.84 – 66.85 MbChr 8: 104.53 – 104.55 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Carbonic anhydrase 7 (CA7) is an enzyme that in humans is encoded by the CA7 gene.[5][6]

Function

Carbonic anhydrases are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. They show extensive diversity in tissue distribution and in their subcellular localization. The cytosolic protein encoded by this gene is predominantly expressed in the salivary glands. Alternative splicing in the coding region results in multiple transcript variants encoding different isoforms.[6]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000168748 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000031883 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:".
  4. ↑ "Mouse PubMed Reference:".
  5. ↑ Montgomery JC, Venta PJ, Eddy RL, Fukushima YS, Shows TB, Tashian RE (Dec 1991). "Characterization of the human gene for a newly discovered carbonic anhydrase, CA VII, and its localization to chromosome 16". Genomics. 11 (4): 835–48. doi:10.1016/0888-7543(91)90006-Z. PMID 1783392.
  6. 1 2 "Entrez Gene: CA7 carbonic anhydrase VII".

Further reading

  • Sly WS, Hu PY (1995). "Human carbonic anhydrases and carbonic anhydrase deficiencies". Annual Review of Biochemistry. 64: 375–401. doi:10.1146/annurev.bi.64.070195.002111. PMID 7574487.
  • Breton S (Jul 2001). "The cellular physiology of carbonic anhydrases". Jop. 2 (4 Suppl): 159–64. PMID 11875253.
  • Rivera C, Voipio J, Kaila K (Jan 2005). "Two developmental switches in GABAergic signalling: the K+-Cl- cotransporter KCC2 and carbonic anhydrase CAVII". The Journal of Physiology. 562 (Pt 1): 27–36. doi:10.1113/jphysiol.2004.077495. PMC 1665491. PMID 15528236.
  • Loftus BJ, Kim UJ, Sneddon VP, Kalush F, Brandon R, Fuhrmann J, Mason T, Crosby ML, Barnstead M, Cronin L, Deslattes Mays A, Cao Y, Xu RX, Kang HL, Mitchell S, Eichler EE, Harris PC, Venter JC, Adams MD (Sep 1999). "Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q". Genomics. 60 (3): 295–308. doi:10.1006/geno.1999.5927. PMID 10493829.
  • Chagnon P, Michaud J, Mitchell G, Mercier J, Marion JF, Drouin E, Rasquin-Weber A, Hudson TJ, Richter A (Dec 2002). "A missense mutation (R565W) in cirhin (FLJ14728) in North American Indian childhood cirrhosis". American Journal of Human Genetics. 71 (6): 1443–9. doi:10.1086/344580. PMC 378590. PMID 12417987.
  • Vullo D, Voipio J, Innocenti A, Rivera C, Ranki H, Scozzafava A, Kaila K, Supuran CT (Feb 2005). "Carbonic anhydrase inhibitors. Inhibition of the human cytosolic isozyme VII with aromatic and heterocyclic sulfonamides". Bioorganic & Medicinal Chemistry Letters. 15 (4): 971–6. doi:10.1016/j.bmcl.2004.12.052. PMID 15686895.


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