Carbamoyl phosphate

Carbamoyl phosphate
Names
IUPAC name
(Carbamoyloxy)phosphonic acid
Identifiers
3D model (JSmol)
ChEBI
ChEMBL
ChemSpider
ECHA InfoCard 100.230.975
KEGG
MeSH Carbamoyl+phosphate
Properties
CH2NO5P2−
Molar mass 141.020 g/mol
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
☒N verify (what is ☑Y☒N ?)
Infobox references

Carbamoyl phosphate is an anion of biochemical significance. In land-dwelling animals, it is an intermediary metabolite in nitrogen disposal through the urea cycle and the synthesis of pyrimidines.

Production

It is produced from bicarbonate, ammonia (derived from amino acids), and phosphate (from ATP). The synthesis is catalysed by the enzyme carbamoyl phosphate synthetase, as follows:

  • HCO−
    3     + ATP → ADP + HO–C(O)–OPO2−
    3     (carboxyl phosphate)
  • HO–C(O)–OPO2−
    3     + NH3 + OH− → HPO2−
    4     + −O–C(O)NH2 + H2O
  • −O–C(O)NH2 + ATP → ADP + H
    2    NC(O)OPO2−
    3

See also

References

  • Nelson, David L.; Cox, Michael M. Lehninger Principles of Biochemistry fourth edition. New York: W. H. Freeman and company.
Pi
+ ATP
PPi + AMP H2O
This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.