Calmegin

CLGN
Identifiers
AliasesCLGN, calmegin
External IDsMGI: 107472 HomoloGene: 68392 GeneCards: CLGN
Gene location (Human)
Chr.Chromosome 4 (human)[1]
Band4q31.1Start140,388,455 bp[1]
End140,427,968 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

1047

12745

Ensembl

ENSG00000153132

ENSMUSG00000002190

UniProt

O14967

P52194

RefSeq (mRNA)

NM_001130675
NM_004362

NM_009904
NM_001329627
NM_001329680

RefSeq (protein)

NP_001124147
NP_004353

NP_001316556
NP_001316609
NP_034034

Location (UCSC)Chr 4: 140.39 – 140.43 MbChr 8: 83.39 – 83.43 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Calmegin, also known as CLGN, is a protein which in humans is encoded by the CLGN gene.[5] Calmegin is also present in other animals including mice.[6]

Function

Calmegin is a testis-specific endoplasmic reticulum chaperone protein. CLGN may play a role in spermatogeneisis and infertility.[5]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000153132 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000002190 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:".
  4. ↑ "Mouse PubMed Reference:".
  5. 1 2 "Entrez Gene: CLGN calmegin".
  6. ↑ Watanabe D, Yamada K, Nishina Y, Tajima Y, Koshimizu U, Nagata A, Nishimune Y (March 1994). "Molecular cloning of a novel Ca(2+)-binding protein (calmegin) specifically expressed during male meiotic germ cell development". J. Biol. Chem. 269 (10): 7744–9. PMID 8126001.

Further reading

  • Watanabe D, Yamada K, Nishina Y, et al. (1994). "Molecular cloning of a novel Ca(2+)-binding protein (calmegin) specifically expressed during male meiotic germ cell development". J. Biol. Chem. 269 (10): 7744–9. PMID 8126001.
  • Ikawa M, Wada I, Kominami K, et al. (1997). "The putative chaperone calmegin is required for sperm fertility". Nature. 387 (6633): 607–11. doi:10.1038/42484. PMID 9177349.
  • Tanaka H, Ikawa M, Tsuchida J, et al. (1998). "Cloning and characterization of the human Calmegin gene encoding putative testis-specific chaperone". Gene. 204 (1–2): 159–63. doi:10.1016/S0378-1119(97)00537-4. PMID 9434179.
  • Yoshinaga K, Tanii I, Toshimori K (1999). "Molecular chaperone calmegin localization to the endoplasmic reticulum of meiotic and post-meiotic germ cells in the mouse testis". Arch. Histol. Cytol. 62 (3): 283–93. doi:10.1679/aohc.62.283. PMID 10495883.
  • Ikawa M, Nakanishi T, Yamada S, et al. (2002). "Calmegin is required for fertilin alpha/beta heterodimerization and sperm fertility". Dev. Biol. 240 (1): 254–61. doi:10.1006/dbio.2001.0462. PMID 11784061.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
  • Kim DH, Shim JS, Kwon HJ (2005). "Coordinated transcriptional regulation of calmegin,a testis-specific molecular chaperon, by histone deacetylase and CpG methyltransferase". Experimental & Molecular Medicine. 37 (5): 492–6. doi:10.1038/emm.2005.61. PMID 16264275.
  • Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.


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