CYREN (protein)

CYREN
Identifiers
Aliases	CYREN, MRI, chromosome 7 open reading frame 49, MRI-2, C7orf49, cell cycle regulator of NHEJ
External IDs	MGI: 1925662 HomoloGene: 49745 GeneCards: CYREN
Gene location (Human)
Chr.	Chromosome 7 (human)[1]
End	135,170,795 bp[1]
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)[2]
End	34,878,060 bp[2]
Gene ontology
Molecular function	• protein binding;
Cellular component	• cytoplasm; • cell nucleus;
Biological process	• double-strand break repair via nonhomologous end joining; • DNA repair; • cellular response to DNA damage stimulus; • negative regulation of double-strand break repair via nonhomologous end joining;
	Sources:Amigo / QuickGO
Orthologs
	78996
	78412
	ENSG00000122783
	ENSMUSG00000046806
	Q9BWK5
	Q8BHZ5
NM_024033; NM_001243749; NM_001243751; NM_001243752; NM_001243753;
	NM_001243754; NM_001243755; NM_001305629; NM_001305630; NM_001363329; NM_001363330
	NM_001135611; NM_199145; NM_001347101
NP_001230678; NP_001230680; NP_001230681; NP_001230682; NP_001230683;
	NP_001230684; NP_001292558; NP_001292559; NP_076938; NP_001350258; NP_001350259
	NP_001129083; NP_001334030; NP_954596
	Wikidata
View/Edit Human	View/Edit Mouse

CYREN (cell cycle regulator of NHEJ) is a protein which prevents classical non-homologous end joining, a method of repair of double-stranded DNA breaks.^[5] This protein is therefore important in regulating DNA repair.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000122783 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000046806 - Ensembl, May 2017
↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
↑ Arnoult, N; Correia, A; Ma, J; Merlo, A; Garcia-Gomez, S; Maric, M; Tognetti, M; Benner, CW; Boulton, SJ; Saghatelian, A; Karlseder, J (20 September 2017). "Regulation of DNA repair pathway choice in S and G2 phases by the NHEJ inhibitor CYREN". Nature. 549 (7673): 548–552. doi:10.1038/nature24023. PMID 28959974.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000122783 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000046806 - Ensembl, May 2017

[3] "Human PubMed Reference:".

[4] "Mouse PubMed Reference:".

[5] Arnoult, N; Correia, A; Ma, J; Merlo, A; Garcia-Gomez, S; Maric, M; Tognetti, M; Benner, CW; Boulton, SJ; Saghatelian, A; Karlseder, J (20 September 2017). "Regulation of DNA repair pathway choice in S and G2 phases by the NHEJ inhibitor CYREN". Nature. 549 (7673): 548–552. doi:10.1038/nature24023. PMID 28959974.