CYB561

CYB561
Identifiers
AliasesCYB561, cytochrome b561, CYB561A1, FRRS2
External IDsMGI: 103253 HomoloGene: 37552 GeneCards: CYB561
Gene location (Human)
Chr.Chromosome 17 (human)[1]
Band17q23.3Start63,432,304 bp[1]
End63,446,378 bp[1]
RNA expression pattern




More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

1534

13056

Ensembl

ENSG00000008283

ENSMUSG00000019590

UniProt

P49447

Q60720

RefSeq (mRNA)

NM_001017916
NM_001017917
NM_001017918
NM_001915
NM_001330421

NM_007805
NM_001356374

RefSeq (protein)

NP_001017916
NP_001017917
NP_001317350
NP_001906

NP_031831
NP_001343303

Location (UCSC)Chr 17: 63.43 – 63.45 MbChr 11: 105.93 – 105.95 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Cytochrome b561 is a protein that in humans is encoded by the CYB561 gene.[5][6]

Model organisms

Model organisms have been used in the study of CYB561 function. A conditional knockout mouse line, called Cyb561tm1a(EUCOMM)Wtsi[13][14] was generated as part of the International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists.[15][16][17]

Male and female animals underwent a standardized phenotypic screen to determine the effects of deletion.[11][18] Twenty three tests were carried out on mutant mice and one significant abnormality was observed: female homozygotes displayed a decreased circulating glucose level after a glucose tolerance test.[11]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000008283 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000019590 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:".
  4. ↑ "Mouse PubMed Reference:".
  5. ↑ McBride OW, Yi HF, Srivastava M (Nov 1994). "The human cytochrome b561 gene (CYB561) is located at 17q11-qter". Genomics. 21 (3): 662–3. doi:10.1006/geno.1994.1332. PMID 7959749.
  6. ↑ "Entrez Gene: CYB561 cytochrome b-561".
  7. ↑ "Dysmorphology data for Cyb561". Wellcome Trust Sanger Institute.
  8. ↑ "Glucose tolerance test data for Cyb561". Wellcome Trust Sanger Institute.
  9. ↑ "Salmonella infection data for Cyb561". Wellcome Trust Sanger Institute.
  10. ↑ "Citrobacter infection data for Cyb561". Wellcome Trust Sanger Institute.
  11. 1 2 3 Gerdin AK (2010). "The Sanger Mouse Genetics Programme: High throughput characterisation of knockout mice". Acta Ophthalmologica. 88: 925–7. doi:10.1111/j.1755-3768.2010.4142.x.
  12. ↑ Mouse Resources Portal, Wellcome Trust Sanger Institute.
  13. ↑ "International Knockout Mouse Consortium".
  14. ↑ "Mouse Genome Informatics".
  15. ↑ Skarnes, W. C.; Rosen, B.; West, A. P.; Koutsourakis, M.; Bushell, W.; Iyer, V.; Mujica, A. O.; Thomas, M.; Harrow, J.; Cox, T.; Jackson, D.; Severin, J.; Biggs, P.; Fu, J.; Nefedov, M.; De Jong, P. J.; Stewart, A. F.; Bradley, A. (2011). "A conditional knockout resource for the genome-wide study of mouse gene function". Nature. 474 (7351): 337–342. doi:10.1038/nature10163. PMC 3572410. PMID 21677750.
  16. ↑ Dolgin E (2011). "Mouse library set to be knockout". Nature. 474 (7351): 262–3. doi:10.1038/474262a. PMID 21677718.
  17. ↑ Collins FS, Rossant J, Wurst W (2007). "A Mouse for All Reasons". Cell. 128 (1): 9–13. doi:10.1016/j.cell.2006.12.018. PMID 17218247.
  18. ↑ van der Weyden L, White JK, Adams DJ, Logan DW (2011). "The mouse genetics toolkit: revealing function and mechanism". Genome Biol. 12 (6): 224. doi:10.1186/gb-2011-12-6-224. PMC 3218837. PMID 21722353.

Further reading

  • Duong LT, Fleming PJ (1982). "Isolation and properties of cytochrome b561 from bovine adrenal chromaffin granules". J. Biol. Chem. 257 (15): 8561–4. PMID 7096323.
  • Srivastava M (1995). "Genomic structure and expression of the human gene encoding cytochrome b561, an integral protein of the chromaffin granule membrane". J. Biol. Chem. 270 (39): 22714–20. doi:10.1074/jbc.270.39.22714. PMID 7559396.
  • Srivastava M, Gibson KR, Pollard HB, Fleming PJ (1994). "Human cytochrome b561: a revised hypothesis for conformation in membranes which reconciles sequence and functional information". Biochem. J. 303 (Pt 3): 915–21. PMC 1137633. PMID 7980462.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Bashtovyy D, Bérczi A, Asard H, Páli T (2004). "Structure prediction for the di-heme cytochrome b561 protein family". Protoplasma. 221 (1–2): 31–40. doi:10.1007/s00709-002-0065-0. PMID 12768339.
  • Kang MK, Kameta A, Shin KH, et al. (2003). "Senescence-associated genes in normal human oral keratinocytes". Exp. Cell Res. 287 (2): 272–81. doi:10.1016/S0014-4827(03)00061-2. PMID 12837283.
  • Vargas JD, Herpers B, McKie AT, et al. (2003). "Stromal cell-derived receptor 2 and cytochrome b561 are functional ferric reductases". Biochim. Biophys. Acta. 1651 (1–2): 116–23. doi:10.1016/S1570-9639(03)00242-5. PMID 14499595.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.


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