CTPS2

CTPS2
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesCTPS2, CTP synthase 2
External IDsMGI: 1933185 HomoloGene: 115908 GeneCards: CTPS2
Gene location (Human)
Chr.X chromosome (human)[1]
BandXp22.2Start16,588,003 bp[1]
End16,712,936 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

56474

55936

Ensembl

ENSG00000047230

ENSMUSG00000031360

UniProt

Q9NRF8

P70303

RefSeq (mRNA)

NM_001144002
NM_019857
NM_175859

NM_001168568
NM_001168569
NM_001168571
NM_018737
NM_001358398

RefSeq (protein)

NP_001137474
NP_062831
NP_787055

NP_001162040
NP_001162041
NP_001162043
NP_061207
NP_001345327

Location (UCSC)Chr X: 16.59 – 16.71 MbChr X: 162.9 – 163.03 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

CTP synthase 2 is an enzyme that in humans is encoded by the CTPS2 gene.[5][6]

The protein encoded by this gene catalyzes the formation of CTP from UTP with the concomitant deamination of glutamine to glutamate. This protein is the rate-limiting enzyme in the synthesis of cytosine nucleotides, which play an important role in various metabolic processes and provide the precursors necessary for the synthesis of RNA and DNA. Cancer cells that exhibit increased cell proliferation also exhibit an increased activity of this encoded protein. Thus, this protein is an attractive target for selective chemotherapy. Two alternatively spliced transcript variants encoding the same protein have been described for this gene.[6]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000047230 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000031360 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:".
  4. ↑ "Mouse PubMed Reference:".
  5. ↑ van Kuilenburg AB, Meinsma R, Vreken P, Waterham HR, van Gennip AH (Oct 2000). "Identification of a cDNA encoding an isoform of human CTP synthetase". Biochim Biophys Acta. 1492 (2–3): 548–52. doi:10.1016/s0167-4781(00)00141-x. PMID 10899599.
  6. 1 2 "Entrez Gene: CTPS2 CTP synthase II".

Further reading

  • Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
  • Han GS, Sreenivas A, Choi MG, et al. (2006). "Expression of Human CTP Synthetase in Saccharomyces cerevisiae Reveals Phosphorylation by Protein Kinase A". J. Biol. Chem. 280 (46): 38328–36. doi:10.1074/jbc.M509622200. PMC 1400552. PMID 16179339.
  • Ross MT, Grafham DV, Coffey AJ, et al. (2005). "The DNA sequence of the human X chromosome". Nature. 434 (7031): 325–37. doi:10.1038/nature03440. PMC 2665286. PMID 15772651.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.


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