CTDSP2

CTDSP2
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesCTDSP2, OS4, PSR2, SCP2, CTD small phosphatase 2
External IDsMGI: 1098748 HomoloGene: 128791 GeneCards: CTDSP2
Gene location (Human)
Chr.Chromosome 12 (human)[1]
Band12q14.1Start57,819,927 bp[1]
End57,846,739 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

10106

52468

Ensembl

ENSG00000175215

ENSMUSG00000078429

UniProt

O14595

Q8BX07

RefSeq (mRNA)

NM_005730

NM_001113470
NM_146012

RefSeq (protein)

NP_005721
NP_005721.3

NP_001106941
NP_666124

Location (UCSC)Chr 12: 57.82 – 57.85 MbChr 10: 126.98 – 127 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 2 is an enzyme that in humans is encoded by the CTDSP2 gene.[5][6][7]

Interactions

CTDSP2 has been shown to interact with SNAI1.[8]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000175215 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000078429 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:".
  4. ↑ "Mouse PubMed Reference:".
  5. ↑ Su YA, Lee MM, Hutter CM, Meltzer PS (Oct 1997). "Characterization of a highly conserved gene (OS4) amplified with CDK4 in human sarcomas". Oncogene. 15 (11): 1289–94. doi:10.1038/sj.onc.1201294. PMID 9315096.
  6. ↑ Yeo M, Lin PS, Dahmus ME, Gill GN (Jul 2003). "A novel RNA polymerase II C-terminal domain phosphatase that preferentially dephosphorylates serine 5". J Biol Chem. 278 (28): 26078–85. doi:10.1074/jbc.M301791200. PMID 12721286.
  7. ↑ "Entrez Gene: CTDSP2 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 2".
  8. ↑ Wu, Yadi; Evers B Mark; Zhou Binhua P (Jan 2009). "Small C-terminal domain phosphatase enhances snail activity through dephosphorylation". J. Biol. Chem. United States. 284 (1): 640–8. doi:10.1074/jbc.M806916200. ISSN 0021-9258. PMC 2610500. PMID 19004823.

Further reading

  • Su YA, Trent JM, Guan XY, Meltzer PS (1994). "Direct isolation of genes encoded within a homogeneously staining region by chromosome microdissection". Proc. Natl. Acad. Sci. U.S.A. 91 (19): 9121–5. Bibcode:1994PNAS...91.9121S. doi:10.1073/pnas.91.19.9121. PMC 44759. PMID 8090779.
  • Beutler E, Gelbart T, West C, et al. (1996). "A strategy for cloning the hereditary hemochromatosis gene". Blood Cells Mol. Dis. 21 (3): 207–16. doi:10.1006/bcmd.1995.0024. PMID 8673473.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Brandenberger R, Wei H, Zhang S, et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
  • Thompson J, Lepikhova T, Teixido-Travesa N, et al. (2006). "Small carboxyl-terminal domain phosphatase 2 attenuates androgen-dependent transcription". EMBO J. 25 (12): 2757–67. doi:10.1038/sj.emboj.7601161. PMC 1500849. PMID 16724108.


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