CTDSP1

CTDSP1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesCTDSP1, NIF3, NLI-IF, NLIIF, SCP1, CTD small phosphatase 1
External IDsMGI: 2654470 HomoloGene: 100834 GeneCards: CTDSP1
Gene location (Human)
Chr.Chromosome 2 (human)[1]
Band2q35Start218,398,256 bp[1]
End218,405,941 bp[1]
Orthologs
SpeciesHumanMouse
Entrez

58190

227292

Ensembl

ENSG00000144579

ENSMUSG00000026176

UniProt

Q9GZU7

P58466

RefSeq (mRNA)

NM_001206878
NM_001206879
NM_021198
NM_182642

NM_153088

RefSeq (protein)

NP_001193807
NP_067021
NP_872580

NP_694728

Location (UCSC)Chr 2: 218.4 – 218.41 MbChr 1: 74.39 – 74.4 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1 is an enzyme that in humans is encoded by the CTDSP1 gene.[5][6][7]

Interactions

CTDSP1 has been shown to interact with SNAI1.[8]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000144579 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000026176 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:".
  4. ↑ "Mouse PubMed Reference:".
  5. ↑ Ma X, Wright J, Dou S, Olsen P, Teeter L, Adams G, Graviss E (Apr 2002). "Ethnic divergence and linkage disequilibrium of novel SNPs in the human NLI-IF gene: evidence of human origin and lack of association with tuberculosis susceptibility". J Hum Genet. 47 (3): 140–5. doi:10.1007/s100380200016. PMID 11950066.
  6. ↑ Yeo M, Lin PS, Dahmus ME, Gill GN (Jul 2003). "A novel RNA polymerase II C-terminal domain phosphatase that preferentially dephosphorylates serine 5". J Biol Chem. 278 (28): 26078–85. doi:10.1074/jbc.M301791200. PMID 12721286.
  7. ↑ "Entrez Gene: CTDSP1 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 1".
  8. ↑ Wu, Yadi; Evers B Mark; Zhou Binhua P (Jan 2009). "Small C-terminal domain phosphatase enhances snail activity through dephosphorylation". J. Biol. Chem. United States. 284 (1): 640–8. doi:10.1074/jbc.M806916200. ISSN 0021-9258. PMC 2610500. PMID 19004823.

Further reading

  • Marquet S, Lepage P, Hudson TJ, et al. (2000). "Complete nucleotide sequence and genomic structure of the human NRAMP1 gene region on chromosome region 2q35". Mamm. Genome. 11 (9): 755–62. doi:10.1007/s003350010151. PMID 10967134.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Fernandes AO, Campagnoni CW, Kampf K, et al. (2004). "Identification of a protein that interacts with the golli-myelin basic protein and with nuclear LIM interactor in the nervous system". J. Neurosci. Res. 75 (4): 461–71. doi:10.1002/jnr.10882. PMID 14743429.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Yeo M, Lee SK, Lee B, et al. (2005). "Small CTD phosphatases function in silencing neuronal gene expression". Science. 307 (5709): 596–600. Bibcode:2005Sci...307..596Y. doi:10.1126/science.1100801. PMID 15681389.
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514.
  • Sapkota G, Knockaert M, Alarcón C, et al. (2007). "Dephosphorylation of the linker regions of Smad1 and Smad2/3 by small C-terminal domain phosphatases has distinct outcomes for bone morphogenetic protein and transforming growth factor-beta pathways". J. Biol. Chem. 281 (52): 40412–9. doi:10.1074/jbc.M610172200. PMID 17085434.


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