CSRP2

CSRP2
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesCSRP2, CRP2, LMO5, SmLIM, cysteine and glycine rich protein 2
External IDsMGI: 1202907 HomoloGene: 111061 GeneCards: CSRP2
Gene location (Human)
Chr.Chromosome 12 (human)[1]
Band12q21.2Start76,858,715 bp[1]
End76,879,060 bp[1]
RNA expression pattern


More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

1466

13008

Ensembl

ENSG00000175183

ENSMUSG00000020186

UniProt

Q16527

P97314

RefSeq (mRNA)

NM_001300965
NM_001321

NM_007792

RefSeq (protein)

NP_001287894
NP_001312

NP_031818

Location (UCSC)Chr 12: 76.86 – 76.88 MbChr 10: 110.92 – 110.94 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Cysteine and glycine-rich protein 2 is a protein that in humans is encoded by the CSRP2 gene.[5][6][7]

CSRP2 is a member of the CSRP family of genes, encoding a group of LIM domain proteins, which may be involved in regulatory processes important for development and cellular differentiation. CRP2 contains two copies of the cysteine-rich amino acid sequence motif (LIM) with putative zinc-binding activity, and may be involved in regulating ordered cell growth. Other genes in the family include CSRP1 and CSRP3.[7]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000175183 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000020186 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:".
  4. ↑ "Mouse PubMed Reference:".
  5. ↑ Weiskirchen R, Pino JD, Macalma T, Bister K, Beckerle MC (Jan 1996). "The cysteine-rich protein family of highly related LIM domain proteins". J Biol Chem. 270 (48): 28946–54. doi:10.1074/jbc.270.48.28946. PMID 7499425.
  6. ↑ Weiskirchen R, Erdel M, Utermann G, Bister K (Nov 1997). "Cloning, structural analysis, and chromosomal localization of the human CSRP2 gene encoding the LIM domain protein CRP2". Genomics. 44 (1): 83–93. doi:10.1006/geno.1997.4855. PMID 9286703.
  7. 1 2 "Entrez Gene: CSRP2 cysteine and glycine-rich protein 2".

Further reading

  • Jain MK, Fujita KP, Hsieh CM, et al. (1996). "Molecular cloning and characterization of SmLIM, a developmentally regulated LIM protein preferentially expressed in aortic smooth muscle cells". J. Biol. Chem. 271 (17): 10194–9. doi:10.1074/jbc.271.17.10194. PMID 8626582.
  • Karim MA, Ohta K, Egashira M, et al. (1997). "Human ESP1/CRP2, a member of the LIM domain protein family: characterization of the cDNA and assignment of the gene locus to chromosome 14q32.3". Genomics. 31 (2): 167–76. doi:10.1006/geno.1996.0028. PMID 8824798.
  • Weiskirchen R, Gressner AM (2000). "The cysteine- and glycine-rich LIM domain protein CRP2 specifically interacts with a novel human protein (CRP2BP)". Biochem. Biophys. Res. Commun. 274 (3): 655–63. doi:10.1006/bbrc.2000.3187. PMID 10924333.
  • Weiskirchen R, Moser M, Weiskirchen S, et al. (2001). "LIM-domain protein cysteine- and glycine-rich protein 2 (CRP2) is a novel marker of hepatic stellate cells and binding partner of the protein inhibitor of activated STAT1". Biochem. J. 359 (Pt 3): 485–96. doi:10.1042/0264-6021:3590485. PMC 1222169. PMID 11672422.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Wang M, Hu Y, Shima I, Stearns ME (2003). "IL-10/IL-10 receptor signaling regulates TIMP-1 expression in primary human prostate tumor lines". Cancer Biol. Ther. 1 (5): 556–63. doi:10.4161/cbt.1.5.222. PMID 12496489.
  • Stearns ME, Wang M, Hu Y, Garcia FU (2004). "Interleukin-10 activation of the interleukin-10E1 pathway and tissue inhibitor of metalloproteinase-1 expression is enhanced by proteasome inhibitors in primary prostate tumor lines". Mol. Cancer Res. 1 (9): 631–42. PMID 12861049.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.


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