CSNK1D

CSNK1D
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3UYS, 3UYT, 3UZP, 4HGT, 4HNF, 4KB8, 4KBA, 4KBC, 4KBK, 4TW9, 4TWC, 4TN6, 5IH6, 5IH5, 5IH4
Identifiers
Aliases	CSNK1D, ASPS, CKIdelta, FASPS2, HCKID, casein kinase 1 delta, CKId, CKI-delta
External IDs	OMIM: 600864 MGI: 1355272 HomoloGene: 74841 GeneCards: CSNK1D
EC number	2.7.11.26
Gene location (Human)
Chr.	Chromosome 17 (human)[1]
End	82,273,731 bp[1]
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)[2]
End	120,991,330 bp[2]
RNA expression pattern
	; ;
	More reference expression data
Gene ontology
Molecular function	• transferase activity; • protein kinase activity; • nucleotide binding; • peptide binding; • kinase activity; • tau-protein kinase activity; • ATP binding; • protein serine/threonine kinase activity; • cadherin binding; • protein binding;
Cellular component	• cytoplasm; • cytosol; • Golgi apparatus; • membrane; • plasma membrane; • spindle; • microtubule organizing center; • spindle microtubule; • perinuclear region of cytoplasm; • neuron projection; • endoplasmic reticulum-Golgi intermediate compartment membrane; • cytoskeleton; • Golgi membrane; • cell nucleus; • centrosome; • nucleoplasm;
Biological process	• cellular response to nerve growth factor stimulus; • positive regulation of protein phosphorylation; • Golgi organization; • phosphorylation; • rhythmic process; • positive regulation of canonical Wnt signaling pathway; • circadian regulation of gene expression; • spindle assembly; • positive regulation of Wnt signaling pathway; • COPII vesicle coating; • G2/M transition of mitotic cell cycle; • regulation of circadian rhythm; • peptidyl-serine phosphorylation; • protein localization to cilium; • protein localization to Golgi apparatus; • protein localization to centrosome; • positive regulation of non-canonical Wnt signaling pathway; • positive regulation of proteasomal ubiquitin-dependent protein catabolic process; • microtubule nucleation; • regulation of cell shape; • endocytosis; • rRNA processing; • Wnt signaling pathway; • ciliary basal body docking; • positive regulation of Wnt-mediated midbrain dopaminergic neuron differentiation; • non-motile cilium assembly; • protein phosphorylation; • regulation of G2/M transition of mitotic cell cycle;
	Sources:Amigo / QuickGO
Orthologs
	1453
	104318
	ENSG00000141551
	ENSMUSG00000025162
	P48730
	Q9DC28
	NM_001893; NM_139062; NM_001363749
	NM_027874; NM_139059
	NP_001884; NP_620693; NP_001350678
	NP_082150; NP_620690
	Wikidata
View/Edit Human	View/Edit Mouse

The CSNK1D gene encodes the casein kinase I isoform delta enzyme in humans.^[5]

This gene is a member of the casein kinase I (CKI) gene family whose members have been implicated in the control of cytoplasmic and nuclear processes, including DNA replication and repair. The encoded protein is highly similar to the mouse and rat CK1 delta homologs. Two transcript variants encoding different isoforms have been found for this gene.^[6]

Interactions

CSNK1D has been shown to interact with Gap junction protein, alpha 1.^[7]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000141551 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000025162 - Ensembl, May 2017
↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
↑ Fish KJ, Cegielska A, Getman ME, Landes GM, Virshup DM (Jul 1995). "Isolation and characterization of human casein kinase I epsilon (CKI), a novel member of the CKI gene family". J Biol Chem. 270 (25): 14875–83. doi:10.1074/jbc.270.25.14875. PMID 7797465.
↑ "Entrez Gene: CSNK1D casein kinase 1, delta".
↑ Cooper, Cynthia D; Lampe Paul D (Nov 2002). "Casein kinase 1 regulates connexin-43 gap junction assembly". J. Biol. Chem. United States. 277 (47): 44962–8. doi:10.1074/jbc.M209427200. ISSN 0021-9258. PMID 12270943.

External links

Human CSNK1D genome location and CSNK1D gene details page in the UCSC Genome Browser.

CSNK1D

Interactions

References

External links

Further reading