CRLF3

CRLF3
Identifiers
AliasesCRLF3, CREME-9, CREME9, CRLM9, CYTOR4, FRWS, p48.2, cytokine receptor like factor 3
External IDsMGI: 1860086 HomoloGene: 9327 GeneCards: CRLF3
Gene location (Human)
Chr.Chromosome 17 (human)[1]
Band17q11.2Start30,769,388 bp[1]
End30,824,776 bp[1]
Orthologs
SpeciesHumanMouse
Entrez

51379

54394

Ensembl

ENSG00000176390

ENSMUSG00000017561

UniProt

Q8IUI8

Q9Z2L7

RefSeq (mRNA)

NM_015986

NM_001277106
NM_018776

RefSeq (protein)

NP_057070

NP_001264035
NP_061246

Location (UCSC)Chr 17: 30.77 – 30.82 MbChr 11: 80.05 – 80.08 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Cytokine receptor-like factor 3 is a protein that in humans is encoded by the CRLF3 gene.[5]

Model organisms

Model organisms have been used in the study of CRLF3 function. A conditional knockout mouse line, called Crlf3tm1a(KOMP)Wtsi[12][13] was generated as part of the International Knockout Mouse Consortium program, a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists.[14][15][16] Male and female animals underwent a standardized phenotypic screen to determine the effects of deletion.[10][17] Twenty six tests were carried out and two significant phenotypes were reported. Homozygous mutant female adults had a significant increase in circulating levels of fructosamine, while mutants of both sexes had decreased platelet cell numbers.[10]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000176390 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000017561 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:".
  4. ↑ "Mouse PubMed Reference:".
  5. ↑ "Entrez Gene: cytokine receptor-like factor 3".
  6. ↑ "Clinical chemistry data for Crlf3". Wellcome Trust Sanger Institute.
  7. ↑ "Haematology data for Crlf3". Wellcome Trust Sanger Institute.
  8. ↑ "Salmonella infection data for Crlf3". Wellcome Trust Sanger Institute.
  9. ↑ "Citrobacter infection data for Crlf3". Wellcome Trust Sanger Institute.
  10. 1 2 3 Gerdin AK (2010). "The Sanger Mouse Genetics Programme: High throughput characterisation of knockout mice". Acta Ophthalmologica. 88 (S248). doi:10.1111/j.1755-3768.2010.4142.x.
  11. ↑ Mouse Resources Portal, Wellcome Trust Sanger Institute.
  12. ↑ "International Knockout Mouse Consortium".
  13. ↑ "Mouse Genome Informatics".
  14. ↑ Skarnes, W. C.; Rosen, B.; West, A. P.; Koutsourakis, M.; Bushell, W.; Iyer, V.; Mujica, A. O.; Thomas, M.; Harrow, J.; Cox, T.; Jackson, D.; Severin, J.; Biggs, P.; Fu, J.; Nefedov, M.; De Jong, P. J.; Stewart, A. F.; Bradley, A. (2011). "A conditional knockout resource for the genome-wide study of mouse gene function". Nature. 474 (7351): 337–342. doi:10.1038/nature10163. PMC 3572410. PMID 21677750.
  15. ↑ Dolgin E (June 2011). "Mouse library set to be knockout". Nature. 474 (7351): 262–3. doi:10.1038/474262a. PMID 21677718.
  16. ↑ Collins FS, Rossant J, Wurst W (January 2007). "A mouse for all reasons". Cell. 128 (1): 9–13. doi:10.1016/j.cell.2006.12.018. PMID 17218247.
  17. ↑ van der Weyden L, White JK, Adams DJ, Logan DW (2011). "The mouse genetics toolkit: revealing function and mechanism". Genome Biol. 12 (6): 224. doi:10.1186/gb-2011-12-6-224. PMC 3218837. PMID 21722353.

Further reading

  • Visser R, Koelma N, Vijfhuizen L, et al. (2009). "RNF135 mutations are not present in patients with Sotos syndrome-like features". Am. J. Med. Genet. A. 149A (4): 806–8. doi:10.1002/ajmg.a.32694. PMID 19291764.
  • Gudbjartsson DF, Walters GB, Thorleifsson G, et al. (2008). "Many sequence variants affecting diversity of adult human height". Nat. Genet. 40 (5): 609–15. doi:10.1038/ng.122. PMID 18391951.
  • Zhao J, Li M, Bradfield JP, et al. (2010). "The role of height-associated loci identified in genome wide association studies in the determination of pediatric stature". BMC Med. Genet. 11: 96. doi:10.1186/1471-2350-11-96. PMC 2894790. PMID 20546612.
  • Yang F, Xu YP, Li J, et al. (2009). "Cloning and characterization of a novel intracellular protein p48.2 that negatively regulates cell cycle progression". Int. J. Biochem. Cell Biol. 41 (11): 2240–50. doi:10.1016/j.biocel.2009.04.022. PMID 19427400.
  • Gevaert K, Goethals M, Martens L, et al. (2003). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides". Nat. Biotechnol. 21 (5): 566–9. doi:10.1038/nbt810. PMID 12665801.
  • Johnatty SE, Beesley J, Chen X, et al. (2010). "Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility "hot-spot"". PLoS Genet. 6 (7): e1001016. doi:10.1371/journal.pgen.1001016. PMC 2900295. PMID 20628624.
  • Barbe L, Lundberg E, Oksvold P, et al. (2008). "Toward a confocal subcellular atlas of the human proteome". Mol. Cell. Proteomics. 7 (3): 499–508. doi:10.1074/mcp.M700325-MCP200. PMID 18029348.
  • Douglas J, Cilliers D, Coleman K, et al. (2007). "Mutations in RNF135, a gene within the NF1 microdeletion region, cause phenotypic abnormalities including overgrowth". Nat. Genet. 39 (8): 963–5. doi:10.1038/ng2083. PMID 17632510.


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