CREB3L1

CREB3L1
Identifiers
Aliases	CREB3L1, OASIS, cAMP responsive element binding protein 3-like 1, cAMP responsive element binding protein 3 like 1, OI16
External IDs	MGI: 1347062 HomoloGene: 8058 GeneCards: CREB3L1
Gene location (Human)
Chr.	Chromosome 11 (human)[1]
End	46,321,422 bp[1]
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)[2]
End	92,024,502 bp[2]
Gene ontology
Molecular function	• DNA binding; • transcription factor activity, sequence-specific DNA binding; • transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding; • chromatin binding; • protein binding; • transcription regulatory region DNA binding; • cAMP response element binding; • SMAD binding; • RNA polymerase II transcription factor activity, sequence-specific DNA binding; • transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding;
Cellular component	• integral component of membrane; • endoplasmic reticulum membrane; • endoplasmic reticulum; • cell nucleus; • membrane; • nuclear chromatin;
Biological process	• negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway; • regulation of transcription, DNA-templated; • extracellular matrix constituent secretion; • positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress; • transcription, DNA-templated; • multicellular organism development; • endoplasmic reticulum unfolded protein response; • response to unfolded protein; • osteoblast differentiation; • positive regulation of transcription from RNA polymerase II promoter; • transcription from RNA polymerase II promoter; • positive regulation of collagen biosynthetic process; • negative regulation of transcription from RNA polymerase II promoter; • negative regulation of gene expression; • negative regulation of fibroblast growth factor receptor signaling pathway; • negative regulation of transcription, DNA-templated; • negative regulation of sprouting angiogenesis;
	Sources:Amigo / QuickGO
Orthologs
	90993
	26427
	ENSG00000157613
	ENSMUSG00000027230
	Q96BA8
	Q9Z125
	NM_052854
	NM_011957
	NP_443086
	NP_036087
	Wikidata
View/Edit Human	View/Edit Mouse

CAMP responsive element binding protein 3 like 1 is a protein that in humans is encoded by the CREB3L1 gene. ^[5]

Function

The protein encoded by this gene is normally found in the membrane of the endoplasmic reticulum (ER). However, upon stress to the ER, the encoded protein is cleaved and the released cytoplasmic transcription factor domain translocates to the nucleus. There it activates the transcription of target genes by binding to box-B elements. [provided by RefSeq, Jun 2013].

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000157613 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000027230 - Ensembl, May 2017
↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
↑ "Entrez Gene: CAMP responsive element binding protein 3 like 1". Retrieved 2017-12-29.

Omori Y, Imai J, Suzuki Y, Watanabe S, Tanigami A, Sugano S (2002). "OASIS is a transcriptional activator of CREB/ATF family with a transmembrane domain". Biochem. Biophys. Res. Commun. 293 (1): 470–7. doi:10.1016/S0006-291X(02)00253-X. PMID 12054625.
Guillou L, Benhattar J, Gengler C, Gallagher G, Ranchère-Vince D, Collin F, Terrier P, Terrier-Lacombe MJ, Leroux A, Marquès B, Aubain Somerhausen Nde S, Keslair F, Pedeutour F, Coindre JM (2007). "Translocation-positive low-grade fibromyxoid sarcoma: clinicopathologic and molecular analysis of a series expanding the morphologic spectrum and suggesting potential relationship to sclerosing epithelioid fibrosarcoma: a study from the French Sarcoma Group". Am. J. Surg. Pathol. 31 (9): 1387–402. doi:10.1097/PAS.0b013e3180321959. PMID 17721195.
Fox RM, Hanlon CD, Andrew DJ (2010). "The CrebA/Creb3-like transcription factors are major and direct regulators of secretory capacity". J. Cell Biol. 191 (3): 479–92. doi:10.1083/jcb.201004062. PMC 3003312. PMID 21041443.
Möller E, Hornick JL, Magnusson L, Veerla S, Domanski HA, Mertens F (2011). "FUS-CREB3L2/L1-positive sarcomas show a specific gene expression profile with upregulation of CD24 and FOXL1". Clin. Cancer Res. 17 (9): 2646–56. doi:10.1158/1078-0432.CCR-11-0145. PMID 21536545.
Denard B, Seemann J, Chen Q, Gay A, Huang H, Chen Y, Ye J (2011). "The membrane-bound transcription factor CREB3L1 is activated in response to virus infection to inhibit proliferation of virus-infected cells". Cell Host Microbe. 10 (1): 65–74. doi:10.1016/j.chom.2011.06.006. PMC 3139916. PMID 21767813.
Denard B, Seemann J, Chen Q, Gay A, Huang H, Chen Y, Ye J (2011). "The membrane-bound transcription factor CREB3L1 is activated in response to virus infection to inhibit proliferation of virus-infected cells". Cell Host Microbe. 10 (1): 65–74. doi:10.1016/j.chom.2011.06.006. PMC 3139916. PMID 21767813.
Debelenko LV, McGregor LM, Shivakumar BR, Dorfman HD, Raimondi SC (2011). "A novel EWSR1-CREB3L1 fusion transcript in a case of small cell osteosarcoma". Genes Chromosomes Cancer. 50 (12): 1054–62. doi:10.1002/gcc.20923. PMID 21987447.
Kondo S, Hino SI, Saito A, Kanemoto S, Kawasaki N, Asada R, Izumi S, Iwamoto H, Oki M, Miyagi H, Kaneko M, Nomura Y, Urano F, Imaizumi K (2012). "Activation of OASIS family, ER stress transducers, is dependent on its stabilization". Cell Death Differ. 19 (12): 1939–49. doi:10.1038/cdd.2012.77. PMC 3504707. PMID 22705851.
Denard B, Lee C, Ye J (2012). "Doxorubicin blocks proliferation of cancer cells through proteolytic activation of CREB3L1". eLife. 1: e00090. doi:10.7554/eLife.00090. PMC 3524649. PMID 23256041.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000157613 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000027230 - Ensembl, May 2017

[3] "Human PubMed Reference:".

[4] "Mouse PubMed Reference:".

[entrez-5] "Entrez Gene: CAMP responsive element binding protein 3 like 1". Retrieved 2017-12-29.

CREB3L1

Function

References

Further reading