CPNE8

CPNE8
Identifiers
AliasesCPNE8, copine 8
External IDsMGI: 1914121 HomoloGene: 12049 GeneCards: CPNE8
Gene location (Human)
Chr.Chromosome 12 (human)[1]
Band12q12Start38,646,822 bp[1]
End38,907,430 bp[1]
Orthologs
SpeciesHumanMouse
Entrez

144402

66871

Ensembl

ENSG00000139117

ENSMUSG00000052560

UniProt

Q86YQ8

Q9DC53

RefSeq (mRNA)

NM_153634

NM_001033851
NM_025815
NM_001357979

RefSeq (protein)

NP_705898

NP_001029023
NP_080091
NP_001344908

Location (UCSC)Chr 12: 38.65 – 38.91 MbChr 15: 90.49 – 90.68 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Copine-8 is a protein that in humans is encoded by the CPNE8 gene.[5][6]

Calcium-dependent membrane-binding proteins may regulate molecular events at the interface of the cell membrane and cytoplasm. This gene is one of several genes that encode a calcium-dependent protein containing two N-terminal type II C2 domains and an integrin A domain-like sequence in the C-terminus.[6]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000139117 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000052560 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:".
  4. ↑ "Mouse PubMed Reference:".
  5. ↑ Maitra R, Grigoryev DN, Bera TK, Pastan IH, Lee B (Apr 2003). "Cloning, molecular characterization, and expression analysis of Copine 8". Biochem Biophys Res Commun. 303 (3): 842–847. doi:10.1016/S0006-291X(03)00445-5. PMID 12670487.
  6. 1 2 "Entrez Gene: CPNE8 copine VIII".

Further reading

  • Creutz CE, Tomsig JL, Snyder SL, et al. (1998). "The copines, a novel class of C2 domain-containing, calcium-dependent, phospholipid-binding proteins conserved from Paramecium to humans". J. Biol. Chem. 273 (3): 1393–1402. doi:10.1074/jbc.273.3.1393. PMID 9430674.
  • Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–1795. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
  • Tomsig JL, Creutz CE (2001). "Biochemical characterization of copine: a ubiquitous Ca2+-dependent, phospholipid-binding protein". Biochemistry. 39 (51): 16163–16175. doi:10.1021/bi0019949. PMID 11123945.
  • Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–435. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Ramsey H, Zhang DE, Richkind K, et al. (2003). "Fusion of AML1/Runx1 to copine VIII, a novel member of the copine family, in an aggressive acute myelogenous leukemia with t(12;21) translocation". Leukemia. 17 (8): 1665–1666. doi:10.1038/sj.leu.2403048. PMID 12886257.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–45. doi:10.1038/ng1285. PMID 14702039.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–2144. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
  • Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–D418. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.


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