CPNE6

CPNE6
Identifiers
AliasesCPNE6, copine 6
External IDsMGI: 1334445 HomoloGene: 81815 GeneCards: CPNE6
Gene location (Human)
Chr.Chromosome 14 (human)[1]
Band14q11.2Start24,070,837 bp[1]
End24,078,100 bp[1]
RNA expression pattern


More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

9362

12891

Ensembl

ENSG00000100884

ENSMUSG00000022212

UniProt

O95741

Q9Z140

RefSeq (mRNA)

NM_001280558
NM_006032

NM_001136057
NM_001146183
NM_009947
NM_001360193

RefSeq (protein)

NP_001267487
NP_006023

NP_001129529
NP_001139655
NP_034077
NP_001347122

Location (UCSC)Chr 14: 24.07 – 24.08 MbChr 14: 55.51 – 55.52 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Copine-6 is a protein that in humans is encoded by the CPNE6 gene.[5][6]

This gene encodes a brain-specific member of the copine family, which is composed of calcium-dependent membrane-binding proteins. The gene product contains two N-terminal C2 domains, and one von Willebrand factor A domain. It may have a role in synaptic plasticity.[6]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000100884 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000022212 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:".
  4. ↑ "Mouse PubMed Reference:".
  5. ↑ Nakayama T, Yaoi T, Yasui M, Kuwajima G (Jul 1998). "N-copine: a novel two C2-domain-containing protein with neuronal activity-regulated expression". FEBS Lett. 428 (1–2): 80–4. doi:10.1016/S0014-5793(98)00497-9. PMID 9645480.
  6. 1 2 "Entrez Gene: CPNE6 copine VI (neuronal)".

Further reading

  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
  • Nakayama T, Yaoi T, Kuwajima G (1999). "Localization and subcellular distribution of N-copine in mouse brain". J. Neurochem. 72 (1): 373–9. doi:10.1046/j.1471-4159.1999.0720373.x. PMID 9886090.
  • Nakayama T, Yaoi T, Kuwajima G, et al. (1999). "Ca2(+)-dependent interaction of N-copine, a member of the two C2 domain protein family, with OS-9, the product of a gene frequently amplified in osteosarcoma". FEBS Lett. 453 (1–2): 77–80. doi:10.1016/S0014-5793(99)00700-0. PMID 10403379.
  • Caudell EG, Caudell JJ, Tang CH, et al. (2000). "Characterization of human copine III as a phosphoprotein with associated kinase activity". Biochemistry. 39 (42): 13034–43. doi:10.1021/bi001250v. PMID 11041869.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.


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