CPNE4

CPNE4
Identifiers
AliasesCPNE4, COPN4, CPN4, copine 4
External IDsMGI: 1921270 HomoloGene: 26078 GeneCards: CPNE4
Gene location (Human)
Chr.Chromosome 3 (human)[1]
Band3q22.1Start131,533,555 bp[1]
End132,285,410 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

131034

74020

Ensembl

ENSG00000196353

ENSMUSG00000032564

UniProt

Q96A23
Q4G168

Q8BLR2

RefSeq (mRNA)

NM_001289112
NM_130808
NM_153429

NM_028719
NM_001357439

RefSeq (protein)

NP_082995
NP_001344368

Location (UCSC)Chr 3: 131.53 – 132.29 MbChr 9: 104.55 – 105.03 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Copine-4 is a protein that in humans is encoded by the CPNE4 gene.[5][6][7]

Calcium-dependent membrane-binding proteins may regulate molecular events at the interface of the cell membrane and cytoplasm. This gene is one of several genes that encode a calcium-dependent protein containing two N-terminal type II C2 domains and an integrin A domain-like sequence in the C-terminus.[7]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000196353 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000032564 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:".
  4. ↑ "Mouse PubMed Reference:".
  5. ↑ Creutz CE, Tomsig JL, Snyder SL, Gautier MC, Skouri F, Beisson J, Cohen J (Feb 1998). "The copines, a novel class of C2 domain-containing, calcium-dependent, phospholipid-binding proteins conserved from Paramecium to humans". J Biol Chem. 273 (3): 1393–402. doi:10.1074/jbc.273.3.1393. PMID 9430674.
  6. ↑ Maitra R, Grigoryev DN, Bera TK, Pastan IH, Lee B (Apr 2003). "Cloning, molecular characterization, and expression analysis of Copine 8". Biochem Biophys Res Commun. 303 (3): 842–7. doi:10.1016/S0006-291X(03)00445-5. PMID 12670487.
  7. 1 2 "Entrez Gene: CPNE4 copine IV".

Further reading

  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Tomsig JL, Snyder SL, Creutz CE (2003). "Identification of targets for calcium signaling through the copine family of proteins. Characterization of a coiled-coil copine-binding motif". J. Biol. Chem. 278 (12): 10048–54. doi:10.1074/jbc.M212632200. PMID 12522145.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.


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