CPEB1

CPEB1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2M13, 2MKH, 2MKK, 2N1O
Identifiers
Aliases	CPEB1, CEBP, CPE-BP1, CPEB, CPEB-1, hCPEB-1, h-CPEB, cytoplasmic polyadenylation element binding protein 1
External IDs	MGI: 108442 HomoloGene: 7278 GeneCards: CPEB1
Gene location (Human)
Chr.	Chromosome 15 (human)[1]
End	82,648,861 bp[1]
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)[2]
End	81,455,465 bp[2]
Gene ontology
Molecular function	• metal ion binding; • mRNA 3'-UTR AU-rich region binding; • translation factor activity, RNA binding; • RNA binding; • nucleic acid binding; • ribosome binding; • translation repressor activity, nucleic acid binding; • mRNA 3'-UTR binding; • translation regulator activity; • protein binding;
Cellular component	• synapse; • cell projection; • cell junction; • neuron projection; • messenger ribonucleoprotein complex; • postsynaptic density; • postsynaptic membrane; • membrane; • P-body; • dendrite; • plasma membrane; • cytoplasm; • cell nucleus; • nucleoplasm; • cytosol;
Biological process	• cellular response to insulin stimulus; • regulation of translation; • negative regulation of cytoplasmic translation; • mRNA processing; • cellular response to amino acid stimulus; • cellular response to hypoxia; • translation; • positive regulation of mRNA polyadenylation;
	Sources:Amigo / QuickGO
Orthologs
	64506
	12877
	ENSG00000277445; ENSG00000214575
	ENSMUSG00000025586
	Q9BZB8
	P70166
NM_030594; NM_001079533; NM_001079534; NM_001079535; NM_001288819;
	NM_001288820
	NM_001252525; NM_001252526; NM_007755; NM_001357107
NP_001073001; NP_001073002; NP_001073003; NP_001275748; NP_001275749;
	NP_085097; NP_001352169; NP_001352170; NP_001352171; NP_001352172; NP_001352173; NP_001352174; NP_001352175; NP_001352176; NP_001352177; NP_001352178; NP_001352179
	NP_001239454; NP_001239455; NP_031781; NP_001344036
	Wikidata
View/Edit Human	View/Edit Mouse

Cytoplasmic polyadenylation element-binding protein 1 is a protein that in humans is encoded by the CPEB1 gene.^[5]^[6]

This gene encodes a member of the cytoplasmic polyadenylation element (CPE) binding protein family. This highly conserved protein binds to a specific RNA sequence called the CPE found in the 3' UTR of some mRNAs. Similar proteins in Xenopus and mouse function to induce cytoplasmic polyadenylation of dormant mRNAs with short polyA tails, resulting in their translation. Members of this protein family regulate translation of cyclin B1 during embryonic cell divisions. Multiple transcript variants encoding different isoforms have been found for this gene.^[6]

References

1 2 3 ENSG00000214575 GRCh38: Ensembl release 89: ENSG00000277445, ENSG00000214575 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000025586 - Ensembl, May 2017
↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
↑ Welk JF, Charlesworth A, Smith GD, MacNicol AM (Mar 2001). "Identification and characterization of the gene encoding human cytoplasmic polyadenylation element binding protein". Gene. 263 (1–2): 113–20. doi:10.1016/S0378-1119(00)00588-6. PMID 11223249.
1 2 "Entrez Gene: CPEB1 cytoplasmic polyadenylation element binding protein 1".

External links

Human CPEB1 genome location and CPEB1 gene details page in the UCSC Genome Browser.

Mendez R, Richter JD (2001). "Translational control by CPEB: a means to the end". Nat. Rev. Mol. Cell Biol. 2 (7): 521–9. doi:10.1038/35080081. PMID 11433366.
"Toward a complete human genome sequence". Genome Res. 8 (11): 1097–108. 1999. doi:10.1101/gr.8.11.1097. PMID 9847074.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Huang YS, Carson JH, Barbarese E, Richter JD (2003). "Facilitation of dendritic mRNA transport by CPEB". Genes Dev. 17 (5): 638–53. doi:10.1101/gad.1053003. PMC 196011. PMID 12629046.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Wilczynska A, Aigueperse C, Kress M, et al. (2005). "The translational regulator CPEB1 provides a link between dcp1 bodies and stress granules". J. Cell Sci. 118 (Pt 5): 981–92. doi:10.1242/jcs.01692. PMID 15731006.
Sasayama T, Marumoto T, Kunitoku N, et al. (2005). "Over-expression of Aurora-A targets cytoplasmic polyadenylation element binding protein and promotes mRNA polyadenylation of Cdk1 and cyclin B1". Genes Cells. 10 (7): 627–38. doi:10.1111/j.1365-2443.2005.00870.x. PMID 15966895.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.

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[refGRCh38Ensembl-1] 1 2 3 ENSG00000214575 GRCh38: Ensembl release 89: ENSG00000277445, ENSG00000214575 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000025586 - Ensembl, May 2017

[3] "Human PubMed Reference:".

[4] "Mouse PubMed Reference:".

[pmid11223249-5] Welk JF, Charlesworth A, Smith GD, MacNicol AM (Mar 2001). "Identification and characterization of the gene encoding human cytoplasmic polyadenylation element binding protein". Gene. 263 (1–2): 113–20. doi:10.1016/S0378-1119(00)00588-6. PMID 11223249.

[entrez-6] 1 2 "Entrez Gene: CPEB1 cytoplasmic polyadenylation element binding protein 1".

CPEB1

References

External links

Further reading