COP1

CARD16
Identifiers
Aliases	CARD16, COP, COP1, PSEUDO-ICE, caspase recruitment domain family member 16
External IDs	HomoloGene: 133086 GeneCards: CARD16
Gene location (Human)
Chr.	Chromosome 11 (human)[1]
End	105,101,431 bp[1]
Gene ontology
Molecular function	• peptidase inhibitor activity; • protein binding; • kinase binding; • identical protein binding; • caspase binding; • CARD domain binding; • cysteine-type endopeptidase inhibitor activity;
Cellular component	• protease inhibitor complex; • macromolecular complex;
Biological process	• regulation of apoptotic process; • negative regulation of peptidase activity; • negative regulation of lipopolysaccharide-mediated signaling pathway; • negative regulation of protein binding; • negative regulation of interleukin-1 beta secretion; • positive regulation of NF-kappaB transcription factor activity; • inhibition of cysteine-type endopeptidase activity; • negative regulation of tumor necrosis factor-mediated signaling pathway; • negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; • cellular response to hypoxia; • cellular response to UV-C; • positive regulation of I-kappaB kinase/NF-kappaB signaling; • cellular response to lipopolysaccharide;
	Sources:Amigo / QuickGO
Orthologs
	114769
	n/a
	ENSG00000204397
	n/a
	Q5EG05
	n/a
	NM_001017534; NM_052889
	n/a
	NP_001017534; NP_443121
	n/a
	Wikidata
View/Edit Human

For the membrane coated vesicle used in transport, see here.

Fagol Caspase recruitment domain-containing protein 16 is an enzyme that in humans is encoded by the CARD16 gene.^[3]^[4]^[5]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000204397 - Ensembl, May 2017
↑ "Human PubMed Reference:".
↑ Lee SH, Stehlik C, Reed JC (Sep 2001). "Cop, a caspase recruitment domain-containing protein and inhibitor of caspase-1 activation processing". J Biol Chem. 276 (37): 34495–500. doi:10.1074/jbc.M101415200. PMID 11432859.
↑ Druilhe A, Srinivasula SM, Razmara M, Ahmad M, Alnemri ES (Sep 2001). "Regulation of IL-1beta generation by Pseudo-ICE and ICEBERG, two dominant negative caspase recruitment domain proteins". Cell Death Differ. 8 (6): 649–57. doi:10.1038/sj.cdd.4400881. PMID 11536016.
↑ "Entrez Gene: COP1 caspase-1 dominant-negative inhibitor pseudo-ICE".

Human CARD16 genome location and CARD16 gene details page in the UCSC Genome Browser.

Wang X, Narayanan M, Bruey JM, et al. (2006). "Protective role of Cop in Rip2/caspase-1/caspase-4-mediated HeLa cell death". Biochim. Biophys. Acta. 1762 (8): 742–54. doi:10.1016/j.bbadis.2006.06.015. PMID 16920334.
Wang X, Wang H, Figueroa BE, et al. (2006). "Dysregulation of receptor interacting protein-2 and caspase recruitment domain only protein mediates aberrant caspase-1 activation in Huntington's disease". J. Neurosci. 25 (50): 11645–54. doi:10.1523/JNEUROSCI.4181-05.2005. PMID 16354923.
Lamkanfi M, Denecker G, Kalai M, et al. (2005). "INCA, a novel human caspase recruitment domain protein that inhibits interleukin-1beta generation". J. Biol. Chem. 279 (50): 51729–38. doi:10.1074/jbc.M407891200. PMID 15383541.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Razmara M, Srinivasula SM, Wang L, et al. (2002). "CARD-8 protein, a new CARD family member that regulates caspase-1 activation and apoptosis". J. Biol. Chem. 277 (16): 13952–8. doi:10.1074/jbc.M107811200. PMID 11821383.

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