CNOT4

CNOT4
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesCNOT4, CLONE243, NOT4, NOT4H, CCR4-NOT transcription complex subunit 4
External IDsMGI: 1859026 HomoloGene: 40870 GeneCards: CNOT4
Gene location (Human)
Chr.Chromosome 7 (human)[1]
Band7q33Start135,361,795 bp[1]
End135,510,127 bp[1]
Orthologs
SpeciesHumanMouse
Entrez

4850

53621

Ensembl

ENSG00000080802

ENSMUSG00000038784

UniProt

O95628

Q8BT14

RefSeq (mRNA)

NM_001164411
NM_001164412
NM_001164413
NM_001164414
NM_016877

RefSeq (protein)

NP_001157883
NP_001157884
NP_001157885
NP_001157886
NP_058573

Location (UCSC)Chr 7: 135.36 – 135.51 MbChr 6: 35.02 – 35.13 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

CCR4-NOT transcription complex, subunit 4 is a protein that in humans is encoded by the CNOT4 gene.[5]

Function

The protein encoded by this gene is a subunit of the CCR4-NOT complex, a global transcriptional regulator. The encoded protein interacts with CNOT1 and has E3 ubiquitin ligase activity. Several transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jul 2010].

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000080802 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000038784 - Ensembl, May 2017
  3. "Human PubMed Reference:".
  4. "Mouse PubMed Reference:".
  5. "Entrez Gene: CCR4-NOT transcription complex, subunit 4".

Further reading

  • Grönholm J, Kaustio M, Myllymäki H, Kallio J, Saarikettu J, Kronhamn J, Valanne S, Silvennoinen O, Rämet M (March 2012). "Not4 enhances JAK/STAT pathway-dependent gene expression in Drosophila and in human cells". FASEB Journal. 26 (3): 1239–50. doi:10.1096/fj.11-195875. PMID 22159038.
  • Winkler GS, Albert TK, Dominguez C, Legtenberg YI, Boelens R, Timmers HT (March 2004). "An altered-specificity ubiquitin-conjugating enzyme/ubiquitin-protein ligase pair". Journal of Molecular Biology. 337 (1): 157–65. doi:10.1016/j.jmb.2004.01.031. PMID 15001359.
  • Lau NC, Kolkman A, van Schaik FM, Mulder KW, Pijnappel WW, Heck AJ, Timmers HT (September 2009). "Human Ccr4-Not complexes contain variable deadenylase subunits". The Biochemical Journal. 422 (3): 443–53. doi:10.1042/BJ20090500. PMID 19558367.
  • Albert TK, Hanzawa H, Legtenberg YI, de Ruwe MJ, van den Heuvel FA, Collart MA, Boelens R, Timmers HT (February 2002). "Identification of a ubiquitin-protein ligase subunit within the CCR4-NOT transcription repressor complex". The EMBO Journal. 21 (3): 355–64. doi:10.1093/emboj/21.3.355. PMC 125831. PMID 11823428.
  • Dominguez C, Bonvin AM, Winkler GS, van Schaik FM, Timmers HT, Boelens R (April 2004). "Structural model of the UbcH5B/CNOT4 complex revealed by combining NMR, mutagenesis, and docking approaches". Structure. 12 (4): 633–44. doi:10.1016/j.str.2004.03.004. PMID 15062086.
  • Wistow G, Bernstein SL, Wyatt MK, Fariss RN, Behal A, Touchman JW, Bouffard G, Smith D, Peterson K (June 2002). "Expressed sequence tag analysis of human RPE/choroid for the NEIBank Project: over 6000 non-redundant transcripts, novel genes and splice variants". Molecular Vision. 8: 205–20. PMID 12107410.
  • Mersman DP, Du HN, Fingerman IM, South PF, Briggs SD (April 2009). "Polyubiquitination of the demethylase Jhd2 controls histone methylation and gene expression". Genes & Development. 23 (8): 951–62. doi:10.1101/gad.1769209. PMC 2675863. PMID 19346402.
  • Hanzawa H, de Ruwe MJ, Albert TK, van Der Vliet PC, Timmers HT, Boelens R (March 2001). "The structure of the C4C4 ring finger of human NOT4 reveals features distinct from those of C3HC4 RING fingers". The Journal of Biological Chemistry. 276 (13): 10185–90. doi:10.1074/jbc.M009298200. PMID 11087754.
  • Albert TK, Lemaire M, van Berkum NL, Gentz R, Collart MA, Timmers HT (February 2000). "Isolation and characterization of human orthologs of yeast CCR4-NOT complex subunits". Nucleic Acids Research. 28 (3): 809–17. doi:10.1093/nar/28.3.809. PMC 102560. PMID 10637334.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.