CLUAP1

CLUAP1
Identifiers
AliasesCLUAP1, CFAP22, FAP22, IFT38, clusterin associated protein 1
External IDsMGI: 1924029 HomoloGene: 14831 GeneCards: CLUAP1
Gene location (Human)
Chr.Chromosome 16 (human)[1]
Band16p13.3Start3,500,924 bp[1]
End3,539,048 bp[1]
Orthologs
SpeciesHumanMouse
Entrez

23059

76779

Ensembl

ENSG00000103351

ENSMUSG00000014232

UniProt

Q96AJ1

Q8R3P7

RefSeq (mRNA)

NM_015041
NM_024793
NM_001330454

NM_029738

RefSeq (protein)

NP_001317383
NP_055856
NP_079069

NP_084014

Location (UCSC)Chr 16: 3.5 – 3.54 MbChr 16: 3.91 – 3.94 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Clusterin associated protein 1, also known as CLUAP1, is a human gene.[5]

Model organisms

Model organisms have been used in the study of CLUAP1 function. A conditional knockout mouse line, called Cluap1tm1a(KOMP)Wtsi[11][12] was generated as part of the International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists.[13][14][15]

Male and female animals underwent a standardized phenotypic screen to determine the effects of deletion.[9][16] Twenty six tests were carried out on mutant mice and four significant abnormalities were observed.[9] No homozygous mutant embryos were identified during gestation, and therefore none survived until weaning. The remaining tests were carried out on heterozygous mutant adult mice; both sexes had decreased IgG1 levels while males also displayed abnormal spine curvature resulting in kyphosis.[9]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000103351 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000014232 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:".
  4. ↑ "Mouse PubMed Reference:".
  5. ↑ "Entrez Gene: clusterin associated protein 1". Retrieved 2011-08-30.
  6. ↑ "Radiography data for Cluap1". Wellcome Trust Sanger Institute.
  7. ↑ "Salmonella infection data for Cluap1". Wellcome Trust Sanger Institute.
  8. ↑ "Citrobacter infection data for Cluap1". Wellcome Trust Sanger Institute.
  9. 1 2 3 4 Gerdin AK (2010). "The Sanger Mouse Genetics Programme: High throughput characterisation of knockout mice". Acta Ophthalmologica. 88: 925–7. doi:10.1111/j.1755-3768.2010.4142.x.
  10. ↑ Mouse Resources Portal, Wellcome Trust Sanger Institute.
  11. ↑ "International Knockout Mouse Consortium".
  12. ↑ "Mouse Genome Informatics".
  13. ↑ Skarnes, W. C.; Rosen, B.; West, A. P.; Koutsourakis, M.; Bushell, W.; Iyer, V.; Mujica, A. O.; Thomas, M.; Harrow, J.; Cox, T.; Jackson, D.; Severin, J.; Biggs, P.; Fu, J.; Nefedov, M.; De Jong, P. J.; Stewart, A. F.; Bradley, A. (2011). "A conditional knockout resource for the genome-wide study of mouse gene function". Nature. 474 (7351): 337–342. doi:10.1038/nature10163. PMC 3572410. PMID 21677750.
  14. ↑ Dolgin E (2011). "Mouse library set to be knockout". Nature. 474 (7351): 262–3. doi:10.1038/474262a. PMID 21677718.
  15. ↑ Collins FS, Rossant J, Wurst W (2007). "A Mouse for All Reasons". Cell. 128 (1): 9–13. doi:10.1016/j.cell.2006.12.018. PMID 17218247.
  16. ↑ van der Weyden L, White JK, Adams DJ, Logan DW (2011). "The mouse genetics toolkit: revealing function and mechanism". Genome Biol. 12 (6): 224. doi:10.1186/gb-2011-12-6-224. PMC 3218837. PMID 21722353.

Further reading

  • Rual JF, Venkatesan K, Hao T (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
  • Follit JA, Xu F, Keady BT, Pazour GJ (2009). "Characterization of mouse IFT complex B". Cell Motility and the Cytoskeleton. 66 (8): 457–68. doi:10.1002/cm.20346. PMC 2753169. PMID 19253336.
  • Gerhard DS, Wagner L, Feingold EA (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Research. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Ota T, Suzuki Y, Nishikawa T (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nature Genetics. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Strausberg RL, Feingold EA, Grouse LH (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proceedings of the National Academy of Sciences USA. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Ishikawa K, Nagase T, Suyama M (1998). "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Research. 5 (3): 169–76. doi:10.1093/dnares/5.3.169. PMID 9734811.
  • Takahashi M, Lin YM, Nakamura Y, Furukawa Y (2004). "Isolation and characterization of a novel gene CLUAP1 whose expression is frequently upregulated in colon cancer". Oncogene. 23 (57): 9289–94. doi:10.1038/sj.onc.1208100. PMID 15480429.
  • Ishikura H, Ikeda H, Abe H (2007). "Identification of CLUAP1 as a human osteosarcoma tumor-associated antigen recognized by the humoral immune system". International Journal of Oncology. 30 (2): 461–7. doi:10.3892/ijo.30.2.461. PMID 17203229.
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