CLEC2D

CLEC2D
Available structures
PDBHuman UniProt search: PDBe RCSB
Identifiers
AliasesCLEC2D, CLAX, LLT1, OCIL, C-type lectin domain family 2 member D
External IDsHomoloGene: 137257 GeneCards: CLEC2D
Gene location (Human)
Chr.Chromosome 12 (human)[1]
Band12p13.31Start9,664,969 bp[1]
End9,699,555 bp[1]
Orthologs
SpeciesHumanMouse
Entrez

29121

n/a

Ensembl

ENSG00000069493

n/a

UniProt

Q9UHP7

n/a

RefSeq (mRNA)

n/a

RefSeq (protein)

NP_001004419
NP_001184246
NP_001184247
NP_001184248
NP_037401

n/a

Location (UCSC)Chr 12: 9.66 – 9.7 Mbn/a
PubMed search[2]n/a
Wikidata
View/Edit Human

C-type lectin domain family 2 member D is a protein that in humans is encoded by the CLEC2D gene.[3]

This gene encodes a member of the natural killer cell receptor C-type lectin family. The encoded protein inhibits osteoclast formation and contains a transmembrane domain near the N-terminus as well as the C-type lectin-like extracellular domain. Several alternatively spliced transcript variants have been identified, but the full-length nature of every transcript has not been defined.[3] CLEC2D encodes the gene for the Lectin Like Transcript-1 (LLT1) protein which is a functional ligand for the human NKR-P1A receptor, encoded by the KLRB1 gene. In mice, there are many orthologs of the CLEC2D gene, and the presumed homolog is Clr-b/Ocil (Clec2d). Clr-b has been implicated in missing-self recognition by natural killer cells through engagement of the NKR-P1B receptor.

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000069493 - Ensembl, May 2017
  2. ↑ "Human PubMed Reference:".
  3. 1 2 "Entrez Gene: CLEC2D C-type lectin domain family 2, member D".

Further reading

  • Boles KS, Barten R, Kumaresan PR, et al. (1999). "Cloning of a new lectin-like receptor expressed on human NK cells". Immunogenetics. 50 (1–2): 1–7. doi:10.1007/s002510050679. PMID 10541800.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Iizuka K, Naidenko OV, Plougastel BF, et al. (2003). "Genetically linked C-type lectin-related ligands for the NKRP1 family of natural killer cell receptors". Nat. Immunol. 4 (8): 801–7. doi:10.1038/ni954. PMID 12858173.
  • Hu YS, Zhou H, Myers D, et al. (2004). "Isolation of a human homolog of osteoclast inhibitory lectin that inhibits the formation and function of osteoclasts". J. Bone Miner. Res. 19 (1): 89–99. doi:10.1359/JBMR.0301215. PMID 14753741.
  • Carlyle JR, Jamieson AM, Gasser S, et al. (2004). "Missing self-recognition of Ocil/Clr-b by inhibitory NKR-P1 natural killer cell receptors". Proc. Natl. Acad. Sci. U.S.A. 101 (10): 3527–32. doi:10.1073/pnas.0308304101. PMC 373496. PMID 14990792.
  • Mathew PA, Chuang SS, Vaidya SV, et al. (2004). "The LLT1 receptor induces IFN-gamma production by human natural killer cells". Mol. Immunol. 40 (16): 1157–63. doi:10.1016/j.molimm.2003.11.024. PMID 15104121.
  • Gange CT, Quinn JM, Zhou H, et al. (2004). "Characterization of sugar binding by osteoclast inhibitory lectin". J. Biol. Chem. 279 (28): 29043–9. doi:10.1074/jbc.M312518200. PMID 15123656.
  • Aldemir H, Prod'homme V, Dumaurier MJ, et al. (2006). "Cutting edge: lectin-like transcript 1 is a ligand for the CD161 receptor". J. Immunol. 175 (12): 7791–5. doi:10.4049/jimmunol.175.12.7791. PMID 16339512.
  • Rosen DB, Bettadapura J, Alsharifi M, et al. (2006). "Cutting edge: lectin-like transcript-1 is a ligand for the inhibitory human NKR-P1A receptor". J. Immunol. 175 (12): 7796–9. doi:10.4049/jimmunol.175.12.7796. PMID 16339513.
  • Rosen DB, Cao W, et al. (2008). "Functional Consequences of Interactions between Human NKR-P1A and Its Ligand LLT1 Expressed on Activated Dendritic Cells and B Cells". J. Immunol. 180 (10): 6508–6517. doi:10.4049/jimmunol.180.10.6508. PMC 2577150. PMID 18453569.


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