CLEC2B

CLEC2B
Identifiers
AliasesCLEC2B, AICL, CLECSF2, HP10085, IFNRG1, C-type lectin domain family 2 member B
External IDsHomoloGene: 68443 GeneCards: CLEC2B
Gene location (Human)
Chr.Chromosome 12 (human)[1]
Band12p13.31Start9,852,984 bp[1]
End9,870,136 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

9976

n/a

Ensembl

ENSG00000110852

n/a

UniProt

Q92478

n/a

RefSeq (mRNA)

NM_005127

n/a

RefSeq (protein)

NP_005118

n/a

Location (UCSC)Chr 12: 9.85 – 9.87 Mbn/a
PubMed search[2]n/a
Wikidata
View/Edit Human

C-type lectin domain family 2 member B is a protein that in humans is encoded by the CLEC2B gene.[3][4]

This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response. The encoded type 2 transmembrane protein may function as a cell activation antigen. An alternative splice variant has been described but its full-length sequence has not been determined. This gene is closely linked to other CTL/CTLD superfamily members on chromosome 12p13 in the natural killer gene complex region.[4]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000110852 - Ensembl, May 2017
  2. ↑ "Human PubMed Reference:".
  3. ↑ Hamann J, Montgomery KT, Lau S, Kucherlapati R, van Lier RA (Mar 1997). "AICL: a new activation-induced antigen encoded by the human NK gene complex". Immunogenetics. 45 (5): 295–300. doi:10.1007/s002510050208. PMID 9038101.
  4. 1 2 "Entrez Gene: CLEC2B C-type lectin domain family 2, member B".

Further reading

  • Drickamer K (1999). "C-type lectin-like domains". Curr. Opin. Struct. Biol. 9 (5): 585–90. doi:10.1016/S0959-440X(99)00009-3. PMID 10508765.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Ebner S, Sharon N, Ben-Tal N (2003). "Evolutionary analysis reveals collective properties and specificity in the C-type lectin and lectin-like domain superfamily". Proteins. 53 (1): 44–55. doi:10.1002/prot.10440. PMID 12945048.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Renedo M, Arce I, Montgomery K, et al. (2000). "A sequence-ready physical map of the region containing the human natural killer gene complex on chromosome 12p12.3-p13.2". Genomics. 65 (2): 129–36. doi:10.1006/geno.2000.6163. PMID 10783260.
  • Yokoyama-Kobayashi M, Yamaguchi T, Sekine S, Kato S (1999). "Selection of cDNAs encoding putative type II membrane proteins on the cell surface from a human full-length cDNA bank". Gene. 228 (1–2): 161–7. doi:10.1016/S0378-1119(99)00004-9. PMID 10072769.
  • Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.


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