CLEC12A

CLEC12A
Identifiers
AliasesCLEC12A, CLL-1, CLL1, DCAL-2, MICL, CD371, C-type lectin domain family 12 member A
External IDsMGI: 3040968 HomoloGene: 51378 GeneCards: CLEC12A
Gene location (Human)
Chr.Chromosome 12 (human)[1]
Band12p13.31Start9,951,316 bp[1]
End9,995,694 bp[1]
Orthologs
SpeciesHumanMouse
Entrez

160364

232413

Ensembl

ENSG00000172322

ENSMUSG00000053063

UniProt

Q5QGZ9

Q504P2

RefSeq (mRNA)

NM_001207010
NM_001300730
NM_138337
NM_201623
NM_201625

NM_177686

RefSeq (protein)

NP_001193939
NP_001287659
NP_612210
NP_963917

NP_808354

Location (UCSC)Chr 12: 9.95 – 10 MbChr 6: 129.34 – 129.37 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

C-type lectin domain family 12 member A is a protein that in humans is encoded by the CLEC12A gene.[5]

This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response. The protein encoded by this gene is a negative regulator of granulocyte and monocyte function. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. This gene is closely linked to other CTL/CTLD superfamily members in the natural killer gene complex region on chromosome 12p13.[5]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000172322 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000053063 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:".
  4. ↑ "Mouse PubMed Reference:".
  5. 1 2 "Entrez Gene: CLEC12A C-type lectin domain family 12, member A".

Further reading

  • Drickamer K (1999). "C-type lectin-like domains". Curr. Opin. Struct. Biol. 9 (5): 585–90. doi:10.1016/S0959-440X(99)00009-3. PMID 10508765.
  • van Rhenen A, van Dongen GA, Kelder A, et al. (2007). "The novel AML stem cell associated antigen CLL-1 aids in discrimination between normal and leukemic stem cells". Blood. 110 (7): 2659–66. doi:10.1182/blood-2007-03-083048. PMID 17609428.
  • Marshall AS, Willment JA, Pyz E, et al. (2006). "Human MICL (CLEC12A) is differentially glycosylated and is down-regulated following cellular activation". Eur. J. Immunol. 36 (8): 2159–69. doi:10.1002/eji.200535628. PMID 16838277.
  • Chen CH, Floyd H, Olson NE, et al. (2006). "Dendritic-cell-associated C-type lectin 2 (DCAL-2) alters dendritic-cell maturation and cytokine production". Blood. 107 (4): 1459–67. doi:10.1182/blood-2005-08-3264. PMC 1895401. PMID 16239426.
  • Bakker AB, van den Oudenrijn S, Bakker AQ, et al. (2005). "C-type lectin-like molecule-1: a novel myeloid cell surface marker associated with acute myeloid leukemia". Cancer Res. 64 (22): 8443–50. doi:10.1158/0008-5472.CAN-04-1659. PMID 15548716.
  • Han Y, Zhang M, Li N, et al. (2004). "KLRL1, a novel killer cell lectinlike receptor, inhibits natural killer cell cytotoxicity". Blood. 104 (9): 2858–66. doi:10.1182/blood-2004-03-0878. PMID 15238421.
  • Marshall AS, Willment JA, Lin HH, et al. (2004). "Identification and characterization of a novel human myeloid inhibitory C-type lectin-like receptor (MICL) that is predominantly expressed on granulocytes and monocytes". J. Biol. Chem. 279 (15): 14792–802. doi:10.1074/jbc.M313127200. PMID 14739280.
  • Ebner S, Sharon N, Ben-Tal N (2003). "Evolutionary analysis reveals collective properties and specificity in the C-type lectin and lectin-like domain superfamily". Proteins. 53 (1): 44–55. doi:10.1002/prot.10440. PMID 12945048.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.


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