CISD2

CISD2
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesCISD2, ERIS, Miner1, NAF-1, WFS2, ZCD2, CDGSH iron sulfur domain 2
External IDsMGI: 1914256 HomoloGene: 36436 GeneCards: CISD2
Gene location (Human)
Chr.Chromosome 4 (human)[1]
Band4q24Start102,868,974 bp[1]
End102,892,807 bp[1]
Orthologs
SpeciesHumanMouse
Entrez

493856

67006

Ensembl

ENSG00000145354

ENSMUSG00000028165

UniProt

Q8N5K1

Q9CQB5

RefSeq (mRNA)

NM_001008388

NM_025902

RefSeq (protein)

NP_001008389

NP_080178

Location (UCSC)Chr 4: 102.87 – 102.89 MbChr 3: 135.41 – 135.42 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

CDGSH iron sulfur domain 2 is a protein that in humans is encoded by the CISD2 gene. [5]

Function

The protein encoded by this gene is a zinc finger protein that localizes to the endoplasmic reticulum. The encoded protein binds an iron/sulfur cluster and may be involved in calcium homeostasis. Defects in this gene are a cause of Wolfram syndrome 2. [provided by RefSeq, Mar 2011].

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000145354 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000028165 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:".
  4. ↑ "Mouse PubMed Reference:".
  5. ↑ "Entrez Gene: CDGSH iron sulfur domain 2". Retrieved 2018-06-04.

Further reading

  • Shu SG, Tsai CR, Chi CS (November 2003). "Wolfram syndrome: phenotype and novel mutation in two Taiwanese siblings". J. Formos. Med. Assoc. 102 (11): 808–11. PMID 14724730.
  • Amr S, Heisey C, Zhang M, Xia XJ, Shows KH, Ajlouni K, Pandya A, Satin LS, El-Shanti H, Shiang R (October 2007). "A homozygous mutation in a novel zinc-finger protein, ERIS, is responsible for Wolfram syndrome 2". Am. J. Hum. Genet. 81 (4): 673–83. doi:10.1086/520961. PMC 2227919. PMID 17846994.
  • Conlan AR, Axelrod HL, Cohen AE, Abresch EC, Zuris J, Yee D, Nechushtai R, Jennings PA, Paddock ML (September 2009). "Crystal structure of Miner1: The redox-active 2Fe-2S protein causative in Wolfram Syndrome 2". J. Mol. Biol. 392 (1): 143–53. doi:10.1016/j.jmb.2009.06.079. PMC 2739586. PMID 19580816.
  • Chang NC, Nguyen M, Germain M, Shore GC (February 2010). "Antagonism of Beclin 1-dependent autophagy by BCL-2 at the endoplasmic reticulum requires NAF-1". EMBO J. 29 (3): 606–18. doi:10.1038/emboj.2009.369. PMC 2830692. PMID 20010695.
  • Chen YF, Wu CY, Kirby R, Kao CH, Tsai TF (July 2010). "A role for the CISD2 gene in lifespan control and human disease". Ann. N. Y. Acad. Sci. 1201: 58–64. doi:10.1111/j.1749-6632.2010.05619.x. PMID 20649540.
  • Tamir S, Zuris JA, Agranat L, Lipper CH, Conlan AR, Michaeli D, Harir Y, Paddock ML, Mittler R, Cabantchik ZI, Jennings PA, Nechushtai R (2013). "Nutrient-deprivation autophagy factor-1 (NAF-1): biochemical properties of a novel cellular target for anti-diabetic drugs". PLoS ONE. 8 (5): e61202. doi:10.1371/journal.pone.0061202. PMC 3661554. PMID 23717386.
  • Sohn YS, Tamir S, Song L, Michaeli D, Matouk I, Conlan AR, Harir Y, Holt SH, Shulaev V, Paddock ML, Hochberg A, Cabanchick IZ, Onuchic JN, Jennings PA, Nechushtai R, Mittler R (September 2013). "NAF-1 and mitoNEET are central to human breast cancer proliferation by maintaining mitochondrial homeostasis and promoting tumor growth". Proc. Natl. Acad. Sci. U.S.A. 110 (36): 14676–81. doi:10.1073/pnas.1313198110. PMC 3767537. PMID 23959881.
  • Tamir S, Rotem-Bamberger S, Katz C, Morcos F, Hailey KL, Zuris JA, Wang C, Conlan AR, Lipper CH, Paddock ML, Mittler R, Onuchic JN, Jennings PA, Friedler A, Nechushtai R (April 2014). "Integrated strategy reveals the protein interface between cancer targets Bcl-2 and NAF-1". Proc. Natl. Acad. Sci. U.S.A. 111 (14): 5177–82. doi:10.1073/pnas.1403770111. PMC 3986192. PMID 24706857.
  • Liu L, Xia M, Wang J, Zhang W, Zhang Y, He M (September 2014). "CISD2 expression is a novel marker correlating with pelvic lymph node metastasis and prognosis in patients with early-stage cervical cancer". Med. Oncol. 31 (9): 183. doi:10.1007/s12032-014-0183-5. PMID 25134919.


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