CFLAR

CFLAR
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3H11, 3H13, 2N5R
Identifiers
Aliases	CFLAR, CASH, CASP8AP1, CLARP, Casper, FLAME, FLAME-1, FLAME1, FLIP, I-FLICE, MRIT, c-FLIP, c-FLIPL, c-FLIPR, c-FLIPS, CASP8 and FADD like apoptosis regulator
External IDs	MGI: 1336166 HomoloGene: 7652 GeneCards: CFLAR
Gene location (Human)
Chr.	Chromosome 2 (human)[1]
End	201,176,687 bp[1]
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)[2]
End	58,758,884 bp[2]
RNA expression pattern
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	• cysteine-type peptidase activity; • protein binding; • cysteine-type endopeptidase activity involved in execution phase of apoptosis; • enzyme activator activity; • cysteine-type endopeptidase activity; • peptidase activator activity; • protein heterodimerization activity; • protease binding; • death receptor binding; • macromolecular complex binding; • cysteine-type endopeptidase activity involved in apoptotic process;
Cellular component	• cytosol; • CD95 death-inducing signaling complex; • ripoptosome; • death-inducing signaling complex; • membrane raft; • cytoplasm;
Biological process	• regulation of apoptotic process; • execution phase of apoptosis; • negative regulation of apoptotic process; • proteolysis; • positive regulation of I-kappaB kinase/NF-kappaB signaling; • regulation of necroptotic process; • regulation of extrinsic apoptotic signaling pathway via death domain receptors; • viral process; • apoptotic process; • positive regulation of catalytic activity; • response to hypoxia; • negative regulation of cardiac muscle cell apoptotic process; • positive regulation of neuron projection development; • cellular response to insulin stimulus; • response to testosterone; • positive regulation of ERK1 and ERK2 cascade; • cellular response to epidermal growth factor stimulus; • cellular response to estradiol stimulus; • cellular response to hypoxia; • cellular response to dexamethasone stimulus; • cellular response to nitric oxide; • positive regulation of glomerular mesangial cell proliferation; • positive regulation of extracellular matrix organization; • negative regulation of reactive oxygen species biosynthetic process; • negative regulation of cellular response to transforming growth factor beta stimulus; • negative regulation of hepatocyte apoptotic process; • negative regulation of epithelial cell apoptotic process; • positive regulation of hepatocyte proliferation; • negative regulation of extrinsic apoptotic signaling pathway via death domain receptors; • skeletal muscle tissue development; • positive regulation of peptidase activity; • skeletal muscle atrophy; • regulation of skeletal muscle satellite cell proliferation; • skeletal myofibril assembly; • negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; • skeletal muscle tissue regeneration; • positive regulation of NF-kappaB transcription factor activity; • negative regulation of necroptotic process; • negative regulation of myoblast fusion; • negative regulation of extrinsic apoptotic signaling pathway; • response to bacterium;
	Sources:Amigo / QuickGO
Orthologs
	8837
	12633
	ENSG00000003402
	ENSMUSG00000026031
	O15519
	O35732
NM_001127183; NM_001127184; NM_001202515; NM_001202516; NM_001202517;
	NM_001202518; NM_001202519; NM_001308042; NM_001308043; NM_003879; NM_001351590; NM_001351591; NM_001351592; NM_001351593; NM_001351594
NM_001289704; NM_001293804; NM_001293805; NM_009805; NM_207653;
	NM_001355056
NP_001120655; NP_001120656; NP_001189444; NP_001189445; NP_001189446;
	NP_001189447; NP_001189448; NP_001294971; NP_001294972; NP_003870; NP_001338519; NP_001338520; NP_001338521; NP_001338522; NP_001338523
NP_001276633; NP_001280733; NP_001280734; NP_033935; NP_997536;
	NP_001341985
	Wikidata
View/Edit Human	View/Edit Mouse

CASP8 and FADD-like apoptosis regulator is a protein that in humans is encoded by the CFLAR gene.^[5]^[6] Also called c-FLIP (FLICE-like inhibitory protein).

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000003402 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000026031 - Ensembl, May 2017
↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
↑ Shu HB, Halpin DR, Goeddel DV (Jul 1997). "Casper is a FADD- and caspase-related inducer of apoptosis". Immunity. 6 (6): 751–63. doi:10.1016/S1074-7613(00)80450-1. PMID 9208847.
↑ Irmler M, Thome M, Hahne M, Schneider P, Hofmann K, Steiner V, Bodmer JL, Schroter M, Burns K, Mattmann C, Rimoldi D, French LE, Tschopp J (Jul 1997). "Inhibition of death receptor signals by cellular FLIP". Nature. 388 (6638): 190–5. doi:10.1038/40657. PMID 9217161.

External links

Human CFLAR genome location and CFLAR gene details page in the UCSC Genome Browser.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000003402 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000026031 - Ensembl, May 2017

[3] "Human PubMed Reference:".

[4] "Mouse PubMed Reference:".

[pmid9208847-5] Shu HB, Halpin DR, Goeddel DV (Jul 1997). "Casper is a FADD- and caspase-related inducer of apoptosis". Immunity. 6 (6): 751–63. doi:10.1016/S1074-7613(00)80450-1. PMID 9208847.

[pmid9217161-6] Irmler M, Thome M, Hahne M, Schneider P, Hofmann K, Steiner V, Bodmer JL, Schroter M, Burns K, Mattmann C, Rimoldi D, French LE, Tschopp J (Jul 1997). "Inhibition of death receptor signals by cellular FLIP". Nature. 388 (6638): 190–5. doi:10.1038/40657. PMID 9217161.

CFLAR

References

Further reading

External links