CELA3A

CELA3A
Identifiers
AliasesCELA3A, ELA3, ELA3A, chymotrypsin like elastase family member 3A
External IDsMGI: 3651647 HomoloGene: 129880 GeneCards: CELA3A
Gene location (Human)
Chr.Chromosome 1 (human)[1]
Band1p36.12Start22,001,656 bp[1]
End22,012,539 bp[1]
Orthologs
SpeciesHumanMouse
Entrez

10136

242711

Ensembl

ENSG00000142789

ENSMUSG00000078520

UniProt

P09093

A2A9U8

RefSeq (mRNA)

NM_005747

NM_001126318

RefSeq (protein)

NP_005738

NP_001119790

Location (UCSC)Chr 1: 22 – 22.01 MbChr 4: 137.4 – 137.41 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Chymotrypsin-like elastase family member 3A is an enzyme that in humans is encoded by the CELA3A gene.[5][6][7]

Function

Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six elastase genes which encode the structurally similar proteins elastase 1, 2, 2A, 2B, 3A, and 3B. Unlike other elastases, elastase 3A has little elastolytic activity. Like most of the human elastases, elastase 3A is secreted from the pancreas as a zymogen and, like other serine proteases such as trypsin, chymotrypsin and kallikrein, it has a digestive function in the intestine. Elastase 3A preferentially cleaves proteins after alanine residues. Elastase 3A may also function in the intestinal transport and metabolism of cholesterol. Both elastase 3A and elastase 3B have been referred to as protease E and as elastase 1.[7]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000142789 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000078520 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:".
  4. ↑ "Mouse PubMed Reference:".
  5. ↑ Tani T, Ohsumi J, Mita K, Takiguchi Y (Feb 1988). "Identification of a novel class of elastase isozyme, human pancreatic elastase III, by cDNA and genomic gene cloning". J Biol Chem. 263 (3): 1231–9. PMID 2826474.
  6. ↑ Shirasu Y, Takemura K, Yoshida H, Sato Y, Iijima H, Shimada Y, Mikayama T, Ozawa T, Ikeda N, Ishida A, et al. (Dec 1988). "Molecular cloning of complementary DNA encoding one of the human pancreatic protease E isozymes". J Biochem. 104 (2): 259–64. PMID 2460440.
  7. 1 2 "Entrez Gene: ELA3A elastase 3A, pancreatic".

Further reading

  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Shimada S, Yamaguchi K, Takahashi M, Ogawa M (2002). "Pancreatic elastase IIIA and its variants are expressed in pancreatic carcinoma cells". Int. J. Mol. Med. 10 (5): 599–603. doi:10.3892/ijmm.10.5.599. PMID 12373299.
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
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