CDK5RAP3

CDK5RAP3
Identifiers
AliasesCDK5RAP3, C53, HSF-27, IC53, LZAP, MST016, OK/SW-cl.114, PP1553, CDK5 regulatory subunit associated protein 3
External IDsMGI: 1933126 HomoloGene: 12718 GeneCards: CDK5RAP3
Gene location (Human)
Chr.Chromosome 17 (human)[1]
Band17q21.32Start47,967,810 bp[1]
End47,981,774 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

80279

80280

Ensembl

ENSG00000108465

ENSMUSG00000018669

UniProt

Q96JB5

Q99LM2

RefSeq (mRNA)

NM_030248
NM_001308183
NM_001363255
NM_001363256

RefSeq (protein)

NP_001265126
NP_001265127
NP_001265145
NP_001265146
NP_788276

NP_001295112
NP_084524
NP_001350184
NP_001350185

Location (UCSC)Chr 17: 47.97 – 47.98 MbChr 11: 96.91 – 96.92 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

CDK5 regulatory subunit-associated protein 3 is a protein that in humans is encoded by the CDK5RAP3 gene.[5][6]

Neuronal CDC2-like kinase, which is involved in the regulation of neuronal differentiation, is composed of a catalytic subunit, CDK5, and an activating subunit, p25NCK5A. The protein encoded by this gene binds to p25NCK5A and therefore may be involved in neuronal differentiation. The encoded protein, which may be a substrate of neuronal CDC2-like kinase, has also been found in vascular endothelial cells, where it mediates cell proliferation.[6]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000108465 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000018669 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:".
  4. ↑ "Mouse PubMed Reference:".
  5. ↑ Ching YP, Qi Z, Wang JH (Apr 2000). "Cloning of three novel neuronal Cdk5 activator binding proteins". Gene. 242 (1–2): 285–94. doi:10.1016/S0378-1119(99)00499-0. PMID 10721722.
  6. 1 2 "Entrez Gene: CDK5RAP3 CDK5 regulatory subunit associated protein 3".

Further reading

  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
  • Wang X, Ching YP, Lam WH, et al. (2000). "Identification of a common protein association region in the neuronal Cdk5 activator". J. Biol. Chem. 275 (41): 31763–9. doi:10.1074/jbc.M004358200. PMID 10915792.
  • Ching YP, Pang AS, Lam WH, et al. (2002). "Identification of a neuronal Cdk5 activator-binding protein as Cdk5 inhibitor". J. Biol. Chem. 277 (18): 15237–40. doi:10.1074/jbc.C200032200. PMID 11882646.
  • Chen J, Liu B, Liu Y, et al. (2002). "A novel gene IC53 stimulates ECV304 cell proliferation and is upregulated in failing heart". Biochem. Biophys. Res. Commun. 294 (1): 161–6. doi:10.1016/S0006-291X(02)00446-1. PMID 12054757.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Xie YH, He XH, Tang YT, et al. (2003). "Cloning and characterization of human IC53-2, a novel CDK5 activator binding protein". Cell Res. 13 (2): 83–91. doi:10.1038/sj.cr.7290153. PMID 12737517.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Cen H, Zheng S, Fang YM, et al. (2004). "Induction of HSF1 expression is associated with sporadic colorectal cancer". World J. Gastroenterol. 10 (21): 3122–6. PMID 15457556.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Jiang H, Luo S, Li H (2005). "Cdk5 activator-binding protein C53 regulates apoptosis induced by genotoxic stress via modulating the G2/M DNA damage checkpoint". J. Biol. Chem. 280 (21): 20651–9. doi:10.1074/jbc.M413431200. PMID 15790566.
  • Yin X, Warner DR, Roberts EA, et al. (2005). "Novel interaction between nuclear co-activator CBP and the CDK5 activator binding protein - C53". Int. J. Mol. Med. 16 (2): 251–6. doi:10.3892/ijmm.16.2.251. PMID 16012757.
  • Wang J, He X, Luo Y, Yarbrough WG (2006). "A novel ARF-binding protein (LZAP) alters ARF regulation of HDM2". Biochem. J. 393 (Pt 2): 489–501. doi:10.1042/BJ20050960. PMC 1360699. PMID 16173922.
  • Kim E, Chen F, Wang CC, Harrison LE (2006). "CDK5 is a novel regulatory protein in PPARgamma ligand-induced antiproliferation". Int. J. Oncol. 28 (1): 191–4. doi:10.3892/ijo.28.1.191. PMID 16327995.
  • Camargo LM, Collura V, Rain JC, et al. (2007). "Disrupted in Schizophrenia 1 Interactome: evidence for the close connectivity of risk genes and a potential synaptic basis for schizophrenia". Mol. Psychiatry. 12 (1): 74–86. doi:10.1038/sj.mp.4001880. PMID 17043677.
  • Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
  • Stav D, Bar I, Sandbank J (2007). "Usefulness of CDK5RAP3, CCNB2, and RAGE genes for the diagnosis of lung adenocarcinoma". Int. J. Biol. Markers. 22 (2): 108–13. PMID 17549666.
  • Wang J, An H, Mayo MW, et al. (2007). "LZAP, a putative tumor suppressor, selectively inhibits NF-kappaB". Cancer Cell. 12 (3): 239–51. doi:10.1016/j.ccr.2007.07.002. PMID 17785205.


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