CD300LF

CD300LF
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2NMS
Identifiers
Aliases	CD300LF, CD300f, CLM-1, CLM1, IREM-1, IREM1, IgSF13, LMIR3, NKIR, CD300 molecule like family member f
External IDs	MGI: 2442359 HomoloGene: 51396 GeneCards: CD300LF
Gene location (Human)
Chr.	Chromosome 17 (human)[1]
End	74,712,978 bp[1]
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)[2]
End	115,133,992 bp[2]
Gene ontology
Molecular function	• phosphatidylserine binding; • interleukin-4 receptor binding; • ceramide binding; • lipid binding;
Cellular component	• membrane; • integral component of membrane; • plasma membrane;
Biological process	• immune system process; • regulation of immune response; • negative regulation of mast cell activation; • negative regulation of MyD88-dependent toll-like receptor signaling pathway; • TRIF-dependent toll-like receptor signaling pathway; • interleukin-13-mediated signaling pathway; • positive regulation of interleukin-4-mediated signaling pathway; • negative regulation of apoptotic cell clearance; • positive regulation of apoptotic cell clearance;
	Sources:Amigo / QuickGO
Orthologs
	146722
	246746
	ENSG00000186074
	ENSMUSG00000047798
	Q8TDQ1
	Q6SJQ7
NM_001289082; NM_001289083; NM_001289084; NM_001289085; NM_001289086;
	NM_001289087; NM_139018
	NM_001169153; NM_145634; NM_001347648
NP_001276011; NP_001276012; NP_001276013; NP_001276014; NP_001276015;
	NP_001276016; NP_620587
	NP_001162624; NP_001334577; NP_663609
	Wikidata
View/Edit Human	View/Edit Mouse

CMRF35-like molecule 1 is a protein that in humans is encoded by the CD300LF gene.^[5]^[6]

CD300LF is an inhibitory receptor of the Ig superfamily expressed on myeloid cells. It mediates negative regulatory signals by recruiting SHP1 (PTPN6; MIM 176883) or SHIP (INPP5D; MIM 601582) (Sui et al., 2004; Alvarez-Errico et al., 2004).[supplied by OMIM]^[6]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000186074 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000047798 - Ensembl, May 2017
↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
↑ Clark HF, Gurney AL, Abaya E, Baker K, Baldwin D, Brush J, Chen J, Chow B, Chui C, Crowley C, Currell B, Deuel B, Dowd P, Eaton D, Foster J, Grimaldi C, Gu Q, Hass PE, Heldens S, Huang A, Kim HS, Klimowski L, Jin Y, Johnson S, Lee J, Lewis L, Liao D, Mark M, Robbie E, Sanchez C, Schoenfeld J, Seshagiri S, Simmons L, Singh J, Smith V, Stinson J, Vagts A, Vandlen R, Watanabe C, Wieand D, Woods K, Xie MH, Yansura D, Yi S, Yu G, Yuan J, Zhang M, Zhang Z, Goddard A, Wood WI, Godowski P, Gray A (Oct 2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
1 2 "Entrez Gene: CD300LF CD300 molecule-like family member f".

External links

Human CD300LF genome location and CD300LF gene details page in the UCSC Genome Browser.

Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Chung DH, Humphrey MB, Nakamura MC, et al. (2004). "CMRF-35-like molecule-1, a novel mouse myeloid receptor, can inhibit osteoclast formation". J. Immunol. 171 (12): 6541–8. doi:10.4049/jimmunol.171.12.6541. PMID 14662855.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Sui L, Li N, Liu Q, et al. (2004). "IgSF13, a novel human inhibitory receptor of the immunoglobulin superfamily, is preferentially expressed in dendritic cells and monocytes". Biochem. Biophys. Res. Commun. 319 (3): 920–8. doi:10.1016/j.bbrc.2004.05.065. PMID 15184070.
Zhang Z, Henzel WJ (2005). "Signal peptide prediction based on analysis of experimentally verified cleavage sites". Protein Sci. 13 (10): 2819–24. doi:10.1110/ps.04682504. PMC 2286551. PMID 15340161.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Alvarez-Errico D, Aguilar H, Kitzig F, et al. (2005). "IREM-1 is a novel inhibitory receptor expressed by myeloid cells". Eur. J. Immunol. 34 (12): 3690–701. doi:10.1002/eji.200425433. PMID 15549731.
Alvarez-Errico D, Sayós J, López-Botet M (2007). "The IREM-1 (CD300f) inhibitory receptor associates with the p85alpha subunit of phosphoinositide 3-kinase". J. Immunol. 178 (2): 808–16. doi:10.4049/jimmunol.178.2.808. PMID 17202342.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000186074 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000047798 - Ensembl, May 2017

[3] "Human PubMed Reference:".

[4] "Mouse PubMed Reference:".

[pmid12975309-5] Clark HF, Gurney AL, Abaya E, Baker K, Baldwin D, Brush J, Chen J, Chow B, Chui C, Crowley C, Currell B, Deuel B, Dowd P, Eaton D, Foster J, Grimaldi C, Gu Q, Hass PE, Heldens S, Huang A, Kim HS, Klimowski L, Jin Y, Johnson S, Lee J, Lewis L, Liao D, Mark M, Robbie E, Sanchez C, Schoenfeld J, Seshagiri S, Simmons L, Singh J, Smith V, Stinson J, Vagts A, Vandlen R, Watanabe C, Wieand D, Woods K, Xie MH, Yansura D, Yi S, Yu G, Yuan J, Zhang M, Zhang Z, Goddard A, Wood WI, Godowski P, Gray A (Oct 2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.

[entrez-6] 1 2 "Entrez Gene: CD300LF CD300 molecule-like family member f".

CD300LF

References

External links

Further reading