CCNI (gene)

CCNI
Identifiers
AliasesCCNI, CCNI1, CYC1, CYI, cyclin I
External IDsMGI: 1341077 HomoloGene: 4979 GeneCards: CCNI
RNA expression pattern


More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

10983

12453

Ensembl

n/a

ENSMUSG00000063015

UniProt

Q14094

Q9Z2V9

RefSeq (mRNA)

NM_006835

NM_017367

RefSeq (protein)

NP_059063

Location (UCSC)n/aChr 5: 93.18 – 93.21 Mb
PubMed search[2][3]
Wikidata
View/Edit HumanView/Edit Mouse

Cyclin-I is a protein that in humans is encoded by the CCNI gene.[4][5]

The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin shows the highest similarity with cyclin G. The transcript of this gene was found to be expressed constantly during cell cycle progression. The function of this cyclin has not yet been determined.[5]

References

  1. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000063015 - Ensembl, May 2017
  2. ↑ "Human PubMed Reference:".
  3. ↑ "Mouse PubMed Reference:".
  4. ↑ Nakamura T, Sanokawa R, Sasaki YF, Ayusawa D, Oishi M, Mori N (Jan 1996). "Cyclin I: a new cyclin encoded by a gene isolated from human brain". Exp Cell Res. 221 (2): 534–42. doi:10.1006/excr.1995.1406. PMID 7493655.
  5. 1 2 "Entrez Gene: CCNI cyclin I".

Further reading

  • Sun ZL, Zhu Y, Wang FQ, et al. (2007). "Serum proteomic-based analysis of pancreatic carcinoma for the identification of potential cancer biomarkers". Biochim. Biophys. Acta. 1774 (6): 764–71. doi:10.1016/j.bbapap.2007.04.001. PMID 17507299.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Zhu X, Naz RK (1998). "Expression of a novel isoform of cyclin I in human testis". Biochem. Biophys. Res. Commun. 249 (1): 56–60. doi:10.1006/bbrc.1998.9052. PMID 9705831.
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.


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