CCDC90B

CCDC90B
Identifiers
AliasesCCDC90B, MDS011, MDS025, coiled-coil domain containing 90B
External IDsMGI: 1913615 HomoloGene: 23328 GeneCards: CCDC90B
Gene location (Human)
Chr.Chromosome 11 (human)[1]
Band11q14.1Start83,259,097 bp[1]
End83,286,407 bp[1]
Orthologs
SpeciesHumanMouse
Entrez

60492

66365

Ensembl

ENSG00000137500

ENSMUSG00000030613

UniProt

Q9GZT6

Q8C3X2

RefSeq (mRNA)

NM_001162918
NM_025515

RefSeq (protein)

NP_001156390
NP_079791

Location (UCSC)Chr 11: 83.26 – 83.29 MbChr 7: 92.56 – 92.58 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Coiled coil domain containing 90B, also known as CCDC90B, is a protein encoded by the CCDC90B gene.

Gene

CCDC90B is located on chromosome 11 in humans. It is neighbored by:[5]

  • PCF11, a mammalian pre-mRNA cleavage complex 2 protein
  • ANKRD42, ankyrin repeat protein involved with calcium ion bonding
  • BC070093
  • DLG2, a member of the membrane-associated guanylate kinase (MAGUK) family

Protein

Structure

This protein is characterized by the presence of a domain of unknown function, DUF1640. This domain is a characteristic of the entire protein with the exception of the first twenty-three amino acid residues - MNSRQAWRLFLSQGRGDRWVSRP - which are a mitochondrial targeting site and cleaved.

The protein has seven predicted alpha helices, a characteristic of coiled-coil proteins.

Predicted Properties

Molecular Weight: 26.72 kDa

Isoelectric point: 7.5

Transmembrane Helices: None

Post-translation modifications:[6]

Chloroplast transit peptides: None
Signal pepties: None
C-mannosylation sites: None
N-glycosylation sites: None
Mitochondrial targeting: Yes
Cleaved site: MNSRQAWRLFLSQGRGDRWVSRP

Cellular Location

CCDC90B is presumably a mitochondrial protein. It is predicted to contain at least three specific phosphorylation sites: Protein Kinase C Phosphorylation sites, Casein Kinase II Phosphorylation sites, and cAMP/cGMP Dependant Phosphorylation sites.

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000137500 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000030613 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:".
  4. ↑ "Mouse PubMed Reference:".
  5. ↑ "UCSC Genome Bioinformatics BLAT". University of California - Santa Cruz. March 2006. Retrieved 2009-05-14.
  6. ↑ "ExPASy". SIB Switzerland. 2009-01-05. Retrieved 2009-05-14.
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