CCDC85B

CCDC85B
Identifiers
AliasesCCDC85B, DIPA, coiled-coil domain containing 85B
External IDsMGI: 2147607 HomoloGene: 4989 GeneCards: CCDC85B
Gene location (Human)
Chr.Chromosome 11 (human)[1]
Band11q13.1Start65,890,112 bp[1]
End65,891,635 bp[1]
RNA expression pattern


More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

11007

240514

Ensembl

ENSG00000175602

ENSMUSG00000095098

UniProt

Q15834

Q6PDY0

RefSeq (mRNA)

NM_006848

NM_001243307
NM_198616

RefSeq (protein)

NP_006839

NP_001230236
NP_941018

Location (UCSC)Chr 11: 65.89 – 65.89 MbChr 19: 5.46 – 5.46 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Coiled-coil domain-containing protein 85B is a protein that in humans is encoded by the CCDC85B gene.[5][6][7]

Function

Hepatitis delta virus (HDV) is a pathogenic human virus whose RNA genome and replication cycle resemble those of plant viroids. Delta-interacting protein A (DIPA), a cellular gene product, has been found to have homology to hepatitis delta virus antigen (HDAg). DIPA interacts with the viral antigen, HDAg, and can affect HDV replication in vitro.[7]

Interactions

CCDC85B has been shown to interact with:

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000175602 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000095098 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:".
  4. ↑ "Mouse PubMed Reference:".
  5. ↑ Brazas R, Ganem D (Oct 1996). "A cellular homolog of hepatitis delta antigen: implications for viral replication and evolution". Science. 274 (5284): 90–4. doi:10.1126/science.274.5284.90. PMID 8810253.
  6. ↑ Bezy O, Elabd C, Cochet O, Petersen RK, Kristiansen K, Dani C, Ailhaud G, Amri EZ (Mar 2005). "Delta-interacting protein A, a new inhibitory partner of CCAAT/enhancer-binding protein beta, implicated in adipocyte differentiation". The Journal of Biological Chemistry. 280 (12): 11432–8. doi:10.1074/jbc.M411741200. PMID 15644333.
  7. 1 2 "Entrez Gene: CCDC85B coiled-coil domain containing 85B".
  8. 1 2 3 4 Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, et al. (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.

Further reading

  • Robertson HD (Oct 1996). "How did replicating and coding RNAs first get together?". Science. 274 (5284): 66–7. doi:10.1126/science.274.5284.66. PMID 8848724.
  • Long M, de Souza SJ, Gilbert W (May 1997). "Delta-interacting protein A and the origin of hepatitis delta antigen". Science. 276 (5313): 824–5. doi:10.1126/science.276.5313.824. PMID 9115212.
  • Schumacher B, Schertel C, Wittenburg N, Tuck S, Mitani S, Gartner A, Conradt B, Shaham S (Feb 2005). "C. elegans ced-13 can promote apoptosis and is induced in response to DNA damage". Cell Death and Differentiation. 12 (2): 153–61. doi:10.1038/sj.cdd.4401539. PMID 15605074.
  • Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
  • Lim J, Hao T, Shaw C, Patel AJ, Szabó G, Rual JF, Fisk CJ, Li N, Smolyar A, Hill DE, Barabási AL, Vidal M, Zoghbi HY (May 2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569.
  • Du X, Wang Q, Hirohashi Y, Greene MI (Dec 2006). "DIPA, which can localize to the centrosome, associates with p78/MCRS1/MSP58 and acts as a repressor of gene transcription". Experimental and Molecular Pathology. 81 (3): 184–90. doi:10.1016/j.yexmp.2006.07.008. PMID 17014843.
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