CBX8

CBX8
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3I91, 5EQ0, 2N4Q
Identifiers
Aliases	CBX8, PC3, RC1, chromobox 8
External IDs	MGI: 1353589 HomoloGene: 32199 GeneCards: CBX8
Gene location (Human)
Chr.	Chromosome 17 (human)[1]
End	79,801,683 bp[1]
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)[2]
End	119,040,969 bp[2]
RNA expression pattern
	More reference expression data
Gene ontology
Molecular function	• methylated histone binding; • protein binding; • single-stranded RNA binding; • ubiquitin-protein transferase activator activity;
Cellular component	• ubiquitin ligase complex; • nucleoplasm; • heterochromatin; • PRC1 complex; • nuclear chromatin; • PcG protein complex; • cell nucleus;
Biological process	• positive regulation of collagen biosynthetic process; • regulation of transcription, DNA-templated; • positive regulation of DNA repair; • negative regulation of transcription from RNA polymerase II promoter; • transcription, DNA-templated; • positive regulation of cell proliferation; • regulation of catalytic activity; • histone ubiquitination; • cellular response to hydrogen peroxide; • chromatin organization;
	Sources:Amigo / QuickGO
Orthologs
	57332
	30951
	ENSG00000141570
	ENSMUSG00000025578
	Q9HC52
	Q9QXV1
	NM_020649
	NM_013926
	NP_065700
	NP_038954
	Wikidata
View/Edit Human	View/Edit Mouse

Chromobox protein homolog 8 is a protein that in humans is encoded by the CBX8 gene.^[5]^[6]

Interactions

CBX8 has been shown to interact with RING1^[7] and MLLT1.^[8]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000141570 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000025578 - Ensembl, May 2017
↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
↑ Bardos JI, Saurin AJ, Tissot C, Duprez E, Freemont PS (Oct 2000). "HPC3 is a new human polycomb orthologue that interacts and associates with RING1 and Bmi1 and has transcriptional repression properties". J Biol Chem. 275 (37): 28785–92. doi:10.1074/jbc.M001835200. PMID 10825164.
↑ "Entrez Gene: CBX8 chromobox homolog 8 (Pc class homolog, Drosophila)".
↑ Bárdos, J I; Saurin A J; Tissot C; Duprez E; Freemont P S (Sep 2000). "HPC3 is a new human polycomb orthologue that interacts and associates with RING1 and Bmi1 and has transcriptional repression properties". J. Biol. Chem. UNITED STATES. 275 (37): 28785–92. doi:10.1074/jbc.M001835200. ISSN 0021-9258. PMID 10825164.
↑ García-Cuéllar, M P; Zilles O; Schreiner S A; Birke M; Winkler T H; Slany R K (Jan 2001). "The ENL moiety of the childhood leukemia-associated MLL-ENL oncoprotein recruits human Polycomb 3". Oncogene. England. 20 (4): 411–9. doi:10.1038/sj.onc.1204108. ISSN 0950-9232. PMID 11313972.

External links

Human CBX8 genome location and CBX8 gene details page in the UCSC Genome Browser.

García-Cuéllar MP, Zilles O, Schreiner SA, et al. (2001). "The ENL moiety of the childhood leukemia-associated MLL-ENL oncoprotein recruits human Polycomb 3". Oncogene. 20 (4): 411–9. doi:10.1038/sj.onc.1204108. PMID 11313972.
Hemenway CS, de Erkenez AC, Gould GC (2001). "The polycomb protein MPc3 interacts with AF9, an MLL fusion partner in t(9;11)(p22;q23) acute leukemias". Oncogene. 20 (29): 3798–805. doi:10.1038/sj.onc.1204478. PMID 11439343.
Levine SS, Weiss A, Erdjument-Bromage H, et al. (2002). "The core of the polycomb repressive complex is compositionally and functionally conserved in flies and humans". Mol. Cell. Biol. 22 (17): 6070–8. doi:10.1128/MCB.22.17.6070-6078.2002. PMC 134016. PMID 12167701.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Obuse C, Yang H, Nozaki N, et al. (2004). "Proteomics analysis of the centromere complex from HeLa interphase cells: UV-damaged DNA binding protein 1 (DDB-1) is a component of the CEN-complex, while BMI-1 is transiently co-localized with the centromeric region in interphase". Genes Cells. 9 (2): 105–20. doi:10.1111/j.1365-2443.2004.00705.x. PMID 15009096.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Stelzl U, Worm U, Lalowski M, et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. PMID 16169070.
Dietrich N, Bracken AP, Trinh E, et al. (2007). "Bypass of senescence by the polycomb group protein CBX8 through direct binding to the INK4A-ARF locus". EMBO J. 26 (6): 1637–48. doi:10.1038/sj.emboj.7601632. PMC 1829390. PMID 17332741.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000141570 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000025578 - Ensembl, May 2017

[3] "Human PubMed Reference:".

[4] "Mouse PubMed Reference:".

[pmid10825164-5] Bardos JI, Saurin AJ, Tissot C, Duprez E, Freemont PS (Oct 2000). "HPC3 is a new human polycomb orthologue that interacts and associates with RING1 and Bmi1 and has transcriptional repression properties". J Biol Chem. 275 (37): 28785–92. doi:10.1074/jbc.M001835200. PMID 10825164.

[entrez-6] "Entrez Gene: CBX8 chromobox homolog 8 (Pc class homolog, Drosophila)".

[autogenerated1-7] Bárdos, J I; Saurin A J; Tissot C; Duprez E; Freemont P S (Sep 2000). "HPC3 is a new human polycomb orthologue that interacts and associates with RING1 and Bmi1 and has transcriptional repression properties". J. Biol. Chem. UNITED STATES. 275 (37): 28785–92. doi:10.1074/jbc.M001835200. ISSN 0021-9258. PMID 10825164.

[pmid11313972-8] García-Cuéllar, M P; Zilles O; Schreiner S A; Birke M; Winkler T H; Slany R K (Jan 2001). "The ENL moiety of the childhood leukemia-associated MLL-ENL oncoprotein recruits human Polycomb 3". Oncogene. England. 20 (4): 411–9. doi:10.1038/sj.onc.1204108. ISSN 0950-9232. PMID 11313972.

CBX8

Interactions

References

External links

Further reading