CA 19-9 (carbohydrate antigen 19-9, also called cancer antigen 19-9[1] or sialylated Lewis (a) antigen) is a tumor marker[2] that is used primarily in the management of pancreatic cancer. CA 19-9 is an antigen defined by monoclonal antibody binding to CA 19-9, the tumor surface marker Sialyl-Lewis A.[3]
Uses
Guidelines from the American Society of Clinical Oncology discourage the use of CA 19-9 as a screening test for cancer, particularly pancreatic cancer. The reason is that the test may be falsely normal (false negative) in many cases, or abnormally elevated in people who have no cancer at all (false positive). The main use of CA 19-9 is therefore to see whether a pancreatic tumor is secreting it; if that is the case, then the levels should fall when the tumor is treated, and they may rise again if the disease recurs.[5]
In people with pancreatic masses, CA 19-9 can be useful in distinguishing between cancer and other diseases of the gland.[1][6]
References
- 1 2 3 4 5 Perkins, G.; Slater, E.; Sanders, G.; Prichard, J. (2003). "Serum tumor markers". American Family Physician. 68 (6): 1075–1082. PMID 14524394.
- ↑ CA-19-9+Antigen at the US National Library of Medicine Medical Subject Headings (MeSH)
- ↑ Magnani, JL (15 June 2004). "The discovery, biology, and drug development of sialyl Lea and sialyl Lex". Archives of Biochemistry and Biophysics. 426 (2): 122–31. doi:10.1016/j.abb.2004.04.008. PMID 15158662.
- ↑ Koprowski H, Herlyn M, Steplewski Z, Sears HF (1981). "Specific antigen in serum of patients with colon carcinoma". Science. 212 (4490): 53–5. doi:10.1126/science.6163212. PMID 6163212.
- 1 2 3 Locker G, Hamilton S, Harris J, Jessup J, Kemeny N, Macdonald J, Somerfield M, Hayes D, Bast R (2006). "ASCO 2006 update of recommendations for the use of tumor markers in gastrointestinal cancer". J. Clin. Oncol. 24 (33): 5313–27. doi:10.1200/JCO.2006.08.2644. PMID 17060676.
- 1 2 3 4 Goonetilleke KS, Siriwardena AK (April 2007). "Systematic review of carbohydrate antigen (CA 19-9) as a biochemical marker in the diagnosis of pancreatic cancer". Eur J Surg Oncol. 33 (3): 266–70. doi:10.1016/j.ejso.2006.10.004. PMID 17097848.
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