CALCOCO2

CALCOCO2
Available structures
PDBHuman UniProt search: PDBe RCSB
Identifiers
AliasesCALCOCO2, NDP52, calcium binding and coiled-coil domain 2
External IDsHomoloGene: 31339 GeneCards: CALCOCO2
Gene location (Human)
Chr.Chromosome 17 (human)[1]
Band17q21.32Start48,830,988 bp[1]
End48,866,522 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

10241

n/a

Ensembl

ENSG00000136436

n/a

UniProt

Q13137

n/a

RefSeq (mRNA)

NM_001261390
NM_001261391
NM_001261393
NM_001261395
NM_005831

n/a

RefSeq (protein)

NP_001248319
NP_001248320
NP_001248322
NP_001248324
NP_005822

n/a

Location (UCSC)Chr 17: 48.83 – 48.87 Mbn/a
PubMed search[2]n/a
Wikidata
View/Edit Human

Calcium-binding and coiled-coil domain-containing protein 2 is a protein that in humans is encoded by the CALCOCO2 gene.[3][4]

The protein encoded by this gene is a subunit of nuclear domain 10 (ND10) bodies. ND10 bodies are nuclear domains appearing immunohistochemically as ten dots per nucleus. They are believed to be associated with the nuclear matrix on the basis of their resistance to nuclease digestion and salt extraction. ND10 proteins are removed from the nucleus by HSV-1 infection and may have a role in viral life cycles.[4]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000136436 - Ensembl, May 2017
  2. ↑ "Human PubMed Reference:".
  3. ↑ Korioth F, Gieffers C, Maul GG, Frey J (Jul 1995). "Molecular characterization of NDP52, a novel protein of the nuclear domain 10, which is redistributed upon virus infection and interferon treatment". J Cell Biol. 130 (1): 1–13. doi:10.1083/jcb.130.1.1. PMC 2120522. PMID 7540613.
  4. 1 2 "Entrez Gene: CALCOCO2 calcium binding and coiled-coil domain 2".

Further reading

  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
  • Sternsdorf T, Jensen K, Züchner D, Will H (1997). "Cellular localization, expression, and structure of the nuclear dot protein 52". J. Cell Biol. 138 (2): 435–48. doi:10.1083/jcb.138.2.435. PMC 2138200. PMID 9230084.
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
  • Florin L, Schäfer F, Sotlar K, et al. (2002). "Reorganization of nuclear domain 10 induced by papillomavirus capsid protein l2". Virology. 295 (1): 97–107. doi:10.1006/viro.2002.1360. PMID 12033769.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Di Y, Li J, Zhang Y, et al. (2004). "HCC-associated protein HCAP1, a variant of GEMIN4, interacts with zinc-finger proteins". J. Biochem. 133 (6): 713–8. doi:10.1093/jb/mvg091. PMID 12869526.
  • Everett RD, Sourvinos G, Leiper C, et al. (2004). "Formation of nuclear foci of the herpes simplex virus type 1 regulatory protein ICP4 at early times of infection: localization, dynamics, recruitment of ICP27, and evidence for the de novo induction of ND10-like complexes". J. Virol. 78 (4): 1903–17. doi:10.1128/JVI.78.4.1903-1917.2004. PMC 369473. PMID 14747555.
  • Colland F, Jacq X, Trouplin V, et al. (2004). "Functional proteomics mapping of a human signaling pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
  • Morriswood B, Ryzhakov G, Puri C, et al. (2007). "T6BP and NDP52 are myosin VI binding partners with potential roles in cytokine signalling and cell adhesion". J. Cell Sci. 120 (Pt 15): 2574–85. doi:10.1242/jcs.007005. PMC 2621013. PMID 17635994.


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