CADM3

CADM3
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesCADM3, BIgR, IGSF4B, NECL1, Necl-1, TSLL1, synCAM3, cell adhesion molecule 3
External IDsMGI: 2137858 HomoloGene: 10919 GeneCards: CADM3
Gene location (Human)
Chr.Chromosome 1 (human)[1]
Band1q23.2Start159,171,609 bp[1]
End159,203,313 bp[1]
Orthologs
SpeciesHumanMouse
Entrez

57863

94332

Ensembl

ENSG00000162706

ENSMUSG00000005338

UniProt

Q8N126

Q99N28

RefSeq (mRNA)

NM_021189
NM_001127173
NM_001346510

NM_053199

RefSeq (protein)

NP_001120645
NP_001333439
NP_067012

NP_444429

Location (UCSC)Chr 1: 159.17 – 159.2 MbChr 1: 173.33 – 173.37 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Cell adhesion molecule 3 is a protein that in humans is encoded by the CADM3 gene.[5][6]

IGSF4B is a brain-specific protein related to the calcium-independent cell-cell adhesion molecules known as nectins (see PVRL3; MIM 607147) (Kakunaga et al., 2005).[6]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000162706 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000005338 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:".
  4. ↑ "Mouse PubMed Reference:".
  5. ↑ Fukuhara H, Kuramochi M, Nobukuni T, Fukami T, Saino M, Maruyama T, Nomura S, Sekiya T, Murakami Y (Sep 2001). "Isolation of the TSLL1 and TSLL2 genes, members of the tumor suppressor TSLC1 gene family encoding transmembrane proteins". Oncogene. 20 (38): 5401–7. doi:10.1038/sj.onc.1204696. PMID 11536053.
  6. 1 2 "Entrez Gene: CADM3 cell adhesion molecule 3".

Further reading

  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Shingai T, Ikeda W, Kakunaga S, et al. (2003). "Implications of nectin-like molecule-2/IGSF4/RA175/SgIGSF/TSLC1/SynCAM1 in cell-cell adhesion and transmembrane protein localization in epithelial cells". J. Biol. Chem. 278 (37): 35421–7. doi:10.1074/jbc.M305387200. PMID 12826663.
  • Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
  • Fukami T, Satoh H, Williams YN, et al. (2004). "Isolation of the mouse Tsll1 and Tsll2 genes, orthologues of the human TSLC1-like genes 1 and 2 (TSLL1 and TSLL2)". Gene. 323: 11–8. doi:10.1016/j.gene.2003.09.018. PMID 14659875.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Zhang Z, Henzel WJ (2005). "Signal peptide prediction based on analysis of experimentally verified cleavage sites". Protein Sci. 13 (10): 2819–24. doi:10.1110/ps.04682504. PMC 2286551. PMID 15340161.
  • Kakunaga S, Ikeda W, Itoh S, et al. (2005). "Nectin-like molecule-1/TSLL1/SynCAM3: a neural tissue-specific immunoglobulin-like cell-cell adhesion molecule localizing at non-junctional contact sites of presynaptic nerve terminals, axons and glia cell processes". J. Cell Sci. 118 (Pt 6): 1267–77. doi:10.1242/jcs.01656. PMID 15741237.
  • Zhou Y, Du G, Hu X, et al. (2005). "Nectin-like molecule 1 is a protein 4.1N associated protein and recruits protein 4.1N from cytoplasm to the plasma membrane". Biochim. Biophys. Acta. 1669 (2): 142–54. doi:10.1016/j.bbamem.2005.01.013. PMID 15893517.
  • Dong X, Xu F, Gong Y, et al. (2006). "Crystal structure of the V domain of human Nectin-like molecule-1/Syncam3/Tsll1/Igsf4b, a neural tissue-specific immunoglobulin-like cell-cell adhesion molecule". J. Biol. Chem. 281 (15): 10610–7. doi:10.1074/jbc.M513459200. PMID 16467305.
  • Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. doi:10.1038/nature04727. PMID 16710414.


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