CACYBP

CACYBP
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesCACYBP, GIG5, S100A6BP, SIP, PNAS-107, calcyclin binding protein
External IDsMGI: 1270839 HomoloGene: 7649 GeneCards: CACYBP
Gene location (Human)
Chr.Chromosome 1 (human)[1]
Band1q25.1Start174,999,163 bp[1]
End175,011,715 bp[1]
RNA expression pattern




More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

27101

12301

Ensembl

ENSG00000116161

ENSMUSG00000014226

UniProt

Q9HB71

Q9CXW3

RefSeq (mRNA)

NM_014412
NM_001007214

NM_009786

RefSeq (protein)

NP_001007215
NP_055227

NP_033916

Location (UCSC)Chr 1: 175 – 175.01 MbChr 1: 160.2 – 160.21 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Calcyclin-binding protein is a protein that in humans is encoded by the CACYBP gene.[5][6][7]

The protein encoded by this gene is a calcyclin binding protein. It may be involved in calcium-dependent ubiquitination and subsequent proteosomal degradation of target proteins. It probably serves as a molecular bridge in ubiquitin E3 complexes and participates in the ubiquitin-mediated degradation of beta-catenin. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene.[7]

Interactions

CACYBP has been shown to interact with SKP1A[8] and SIAH1.[5]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000116161 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000014226 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:".
  4. ↑ "Mouse PubMed Reference:".
  5. 1 2 Matsuzawa SI, Reed JC (Jun 2001). "Siah-1, SIP, and Ebi collaborate in a novel pathway for beta-catenin degradation linked to p53 responses". Mol Cell. 7 (5): 915–26. doi:10.1016/S1097-2765(01)00242-8. PMID 11389839.
  6. ↑ Matsuzawa S, Li C, Ni CZ, Takayama S, Reed JC, Ely KR (Jan 2003). "Structural analysis of Siah1 and its interactions with Siah-interacting protein (SIP)". J Biol Chem. 278 (3): 1837–40. doi:10.1074/jbc.M210263200. PMID 12421809.
  7. 1 2 "Entrez Gene: CACYBP calcyclin binding protein".
  8. ↑ Matsuzawa, S I; Reed J C (May 2001). "Siah-1, SIP, and Ebi collaborate in a novel pathway for beta-catenin degradation linked to p53 responses". Mol. Cell. United States. 7 (5): 915–26. doi:10.1016/S1097-2765(01)00242-8. ISSN 1097-2765. PMID 11389839.

Further reading

  • Filipek A, Jastrzebska B, Nowotny M, et al. (2002). "Ca2+-dependent translocation of the calcyclin-binding protein in neurons and neuroblastoma NB-2a cells". J. Biol. Chem. 277 (23): 21103–9. doi:10.1074/jbc.M111010200. PMID 11927578.
  • Liu WX, Wu J, Zhao Z, et al. (2003). "[Cloning and expression of human calcyclin binding protein (hCacyBP) gene]". Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao. 34 (2): 181–6. PMID 12006993.
  • Filipek A, Jastrzebska B, Nowotny M, Kuznicki J (2002). "CacyBP/SIP, a calcyclin and Siah-1-interacting protein, binds EF-hand proteins of the S100 family". J. Biol. Chem. 277 (32): 28848–52. doi:10.1074/jbc.M203602200. PMID 12042313.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Wu J, Tan X, Peng X, et al. (2004). "Translocation and phosphorylation of calcyclin binding protein during retinoic acid-induced neuronal differentiation of neuroblastoma SH-SY5Y cells". J. Biochem. Mol. Biol. 36 (4): 354–8. doi:10.5483/bmbrep.2003.36.4.354. PMID 12895292.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Santelli E, Leone M, Li C, et al. (2005). "Structural analysis of Siah1-Siah-interacting protein interactions and insights into the assembly of an E3 ligase multiprotein complex". J. Biol. Chem. 280 (40): 34278–87. doi:10.1074/jbc.M506707200. PMID 16085652.
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514.
  • Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
  • Sun S, Ning X, Liu J, et al. (2007). "Overexpressed CacyBP/SIP leads to the suppression of growth in renal cell carcinoma". Biochem. Biophys. Res. Commun. 356 (4): 864–71. doi:10.1016/j.bbrc.2007.03.080. PMID 17400182.


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