Bromhexine

Bromhexine
Clinical data
AHFS/Drugs.com International Drug Names
Pregnancy
category
ATC code
Pharmacokinetic data
Bioavailability 75-80%
Elimination half-life 12 hr
Identifiers
CAS Number
PubChem CID
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
ECHA InfoCard 100.020.622 Edit this at Wikidata
Chemical and physical data
Formula C14H20Br2N2
Molar mass 376.13
3D model (JSmol)
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Bromhexine is an expectorant used in the treatment of respiratory disorders associated with viscid or excessive mucus. In addition, bromhexine has antioxidant properties.[1]

Function

Bromhexine is intended to support the body's mechanisms for clearing mucus from the respiratory tract.

It is secretolytic, increasing the production of serous mucus in the respiratory tract, which makes the phlegm thinner and less viscous. This contributes to a secretomotoric effect, allowing the cilia to more easily transport the phlegm out of the lungs. For this reason it is often added to cough syrups.

Bromhexine is a synthetic derivative of the herbal active ingredient vasicine. It has been shown to increase the proportion of serous bronchial secretion, making it more easily expectorated. It is indicated as "secretolytic therapy in bronchopulmonary diseases associated with abnormal mucus secretion and impaired mucus transport".

Bromhexine is contained in various formulations, high and low strength syrups 8 mg/5 ml, 4 mg/5 ml, tablets and soluble tablets (both with 8 mg bromhexine) and solution for oral use 10 mg/5 ml, adapted to the need of the patients. The posology varies with the age and weight, but there are products for all age groups from infant on. Bromhexine is well established and tolerated.

Sometimes it is replaced by its metabolite ambroxol, as in Mucosolvan or Mucoangin.

Brand names

  • Broncholyte Elixir
  • Bisolvon
  • Paxirasol
  • Barkacin
  • Bromhexin
  • Vasican
  • Bisolex
  • Robitussin Chesty/Forte
  • Duro-Tuss Chesty
  • Benadryl Chesty/Forte
  • Movex
  • Bromex
  • Solvex
  • Mucolyte
  • Brofentol
  • Brofentol Plus
  • Dysolvon
  • Flegamina
  • Ventilate Forte (combination of bromhexine and salbutamol)

References

  1. ↑ Morton, Ian; Hall, Judith (1999). Concise Dictionary of Pharmacological Agents. Springer. p. 55. ISBN 0-7514-0499-3. Retrieved 2009-06-03.
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