Biological warfare in popular culture

Biological warfare (BW) — also known as bacteriological warfare, or germ warfare — has had a presence in popular culture for over 100 years. Public interest in it became intense during the Cold War, especially the 1960s and ‘70s, and continues unabated. This article comprises a list of popular culture works referencing BW or bio-terrorism, but not those pertaining to natural, or unintentional, epidemics.

Literature

(Chronological, then alphabetical within years)

Jack London, in his short story "Yah! Yah! Yah!" (1909), describes a fictional punitive European expedition to a South Pacific island that deliberately exposes a Polynesian population to the measles virus, causing many deaths.
In London's science fiction tale, "The Unparalleled Invasion" (1910), the Western nations wipe out all of China with a biological attack.
James Tiptree, Jr.'s "The Last Flight of Dr. Ain" (1969) is a short science fiction tale about a scientist traveling the world releasing a virus targeted to eliminate humanity before it can destroy all life on Earth via climate change.
Tiptree, Jr.'s "The Screwfly Solution" (1977) is a short horror science fiction story about a disease that turns the human sex drive into a drive to kill.
In Stephen King's novel The Stand (1978), a weaponized strain of influenza (officially known as Project Blue and nicknamed "Captain Trips") is accidentally released from a remote U.S. Army base.
In Frank Herbert's science fiction novel The White Plague (1982), a vengeful molecular biologist creates an artificial plague that kills only women, but for which men are the carriers. He releases it in Ireland (to support terrorists), in England (to oppress the Irish), and in Libya (to train said terrorists), and then holds the governments of the world hostage to his demands lest he release more plagues.
In Tom Clancy's "Executive Orders" (1996), Iran attempts to use a strain of Ebola thought to be airborne to infect and devastate the population of the United States while the government is recovering from a separate issue from the prior novel.
Richard Preston's thriller The Cobra Event (1998) describes an attempted bioterrorism attack on the US with a genetically engineered virus ("Cobra"), that fuses the incurable and highly contagious common cold virus with smallpox. The symptom of the resulting disease ("brain-pox") mimic Lesch-Nyhan syndrome, the common cold, and Nuclear Polyhedrosis Virus.
In Suzanne Collins's book Gregor and the Curse of the Warmbloods (2005), there is a plague, which turns out to be a biological weapon which accidentally infected an innocent bystander prematurely.
Matthew John Lee's thriller novel The Quick and the Dead (2008)^[1] depicts the aftermath of an attack on the British Isles using an enhanced smallpox virus. (The author is credited in later editions as John Matthew Lee.^[2]^[3])
Alex Scarrow's TimeRiders novels (2010–2014) feature the use of a biological weapon, code-named Kosong-ni Virus (after the village that was ground-zero for the virus), that destroys approximately 99% of life on Earth within a few weeks.
In George R. R. Martin's fifth A Song of Ice and Fire novel, A Dance With Dragons (2011), the Yunkai army catapults corpses infected with Pale Mare, a fictional cholera-like disease, over the walls of Meereen as a form of biological warfare. (See Gabriel de Mussis for the historical precedent to this.)
Richard Powers' "Orfeo" (2014), tells the story of Peter Els, a contemporary composer accused of bioterrorism after biohacking musical patterns into the bacterial human pathogen Serratia marcescens
In Chris Ryan's novel Hellfire (2015), a joint bio-terrorism plot by ISIS and Boko Haram involves attempting to release an aerosol of a genetically-modified version of the plague bacterium Yersinia pestis during the London Marathon.
In Terry Hayes's novel 'I Am Pilgrim' (2015), there is an attempt to introduce a bio-engineered strain of smallpox virus into the USA.

Films

(Chronological, then alphabetical within years)

In The Satan Bug (1965), at "Station Three"—a top-secret US bioweapons lab in the Southern California desert—the protagonist investigates the murder of the security chief and the disappearances of the director and head scientist; two lethal bioweapons—a strain of "botulinus" and a recently developed virus (the "Satan Bug") which could wipe out the earth's population in months—are missing.
On Her Majesty's Secret Service (1969), the sixth James Bond film, women are being brainwashed by the villain to disseminate bio-warfare agents throughout the world.
In The Andromeda Strain (1971), although the microbial threat in this science fiction film is a natural one returning to earth with a satellite, the scientific response team comes across germ warfare simulations, strongly indicating that the responsible US government projects were designed to actively search for harmful bio-agents for use in BW.
In The Omega Man (1971), a science fiction film starring Charlton Heston, in 1975, BW between China and Russia kills most of the world's population. The protagonist, a U.S. Army scientist/physician, renders himself immune with an experimental vaccine. (In Richard Matheson's source novel, I Am Legend (1954), the plague is coincident with a great war, but it is unclear that it originated with BW.)
The Crazies (1973), a US Army plane carrying an untested bio-weapon (a virus code-named "Trixie") crashes near a small Pennsylvania town contaminating the water; infected victims either die or become violently homicidal, and heavily armed U.S. troops in NBC suits and gas masks soon arrive.
In the Alien franchise of four British-American films—namely, Alien (1979), Aliens (1986), Alien 3 (1992), and Alien: Resurrection (1997)—a key plot-driving element of the story background is that the "Bioweapons Division" of the sinister "Company" must have a specimen of the creature at all costs even at the expense of the "expendable" humans that get in its way. This is most fully developed in the fourth installment wherein a remote "Army Medical Lab" is attempting—as part of a secret military/commercial partnership—to tame the monster. It will be used in "urban pacification" as well as other, supposedly less malign, purposes, such as materials science and vaccines.
In the Japanese movie Virus (1980), a deadly virus ("MM88") created accidentally by an American geneticist amplifies the potency of any other virus or bacterium it comes into contact with; in 1982, MM88 has been stolen from a lab in the US, and a team of Americans vies with a shady East German scientist to recover it, but fail, and a pandemic, initially known as the "Italian Flu", results.
In Men Behind the Sun (1988), a Hong Kong–Chinese historical war horror film graphically depicting war atrocities at the secret Japanese BW facility Unit 731, during World War II, details the various cruel medical experiments inflicted upon Chinese and Soviet POWs.
In 12 Monkeys (1995), a deadly virus wipes out almost all of humanity in 1996, forcing remaining survivors to live underground. A mysterious group, known as the Army of the Twelve Monkeys, is believed to be behind the virus.
28 Days Later (2002), where a deadly modified rage virus is released by a bioterrorist in Cambridge, destroying the UK
Dasavathaaram (2008) is an Indian Tamil science fiction disaster film about a virus outbreak from a laboratory.
Philosophy of a Knife (2008) is a Russian-American horror film covering the aforementioned Japanese Army's Unit 731, mixing archival footage, interviews, and extremely graphic reenactments of the vile experiments performed there during WWII.
In The Crazies (2010 remake of the 1973 film), the water in a small Iowa town becomes contaminated with "Trixie"—a "Rhabdoviridae prototype" bio-weapon—after a military cargo plane en route to an incinerator in Texas crashes; infected victims become cold, calculating, depraved, bloodthirsty killers.
7aum Arivu (2011) is an Indian science fiction martial arts film about the spreading of an ancient virus.
Jurassic World (2015) and Jurassic World: Fallen Kingdom (2018) are American science fiction films, include a plot of using genetic-engineered dinosaurs as military animals.

Television

(Alphabetical by series)

In The 100, season 1, episode 10, the Grounders infect the exiled Murphy with a hemorrhagic virus, then allow him to escape. While fleeing, he stumbles into area surrounding The Ark survivors' camp and infects those who make contact with him. They then unwittingly spread the virus throughout the camp, which sickens some members and kills others. Lincoln explains to Octavia the Grounders use the virus to "soften up" the enemy before attacking them.
In Between a village is infected with a bioweapon, killing everyone over the age of 21, and the remaining people as soon as they become 21.
Foyle's War, season 4, episode 2 (2006) features a minor outbreak of anthrax after biological weapons research during WWII escapes containment.
In "Place of Angels" (1968), the 23rd episode of Captain Scarlet and the Mysterons (a British puppetry drama), at the "Bacteriological Research Centre" near Manchester, England, activation of a culture of "K14", a synthetic virus, threatens the lives of millions.
In the Falling Skies penultimate episode, "Reunion" (August 23, 2015), an alien known as the Dornia gives the protagonist, Tom Mason, a bioweapon to end an alien invasion of the Earth. After Mason's wife Anne and friend Marty modify the virus to be harmless to humans, Tom sets out to deploy it in the series finale "Reborn" (August 30, 2015). Tom infects himself as the alien queen is draining him of his blood, so the virus passes through Tom's blood into her. As the queen is organically linked to her entire race, the bioweapon destroys them, freeing the Earth from oppression.
In the Sliders series finale, "The Seer" (2000), the main characters land on a world where their enemy, the Kromaggs, were wiped out with a bioweapon. One, Rembrandt Brown, injects himself with the virus (harmless to humans) and returns to Earth Prime in an unresolved cliffhanger in hopes of using it to free his homeworld.
In Season 7 of Star Trek: Deep Space Nine, we find out about a disease which is killing off the Founders; this disease later turns out to have been caused intentionally by Section 31.
In Season 4 of The Americans, Elizabeth and Philip Jennings must work with another KGB spy, William, to acquire and use deadly bioagents. In the first episode of the season, "Glanders," the two aim to acquire the deadly bacterium Burkholderia mallei. Throughout the season, endeavors like this continue and intensify, putting the characters in grave danger. So it goes.

Video games