Bart De Strooper

Bart De Strooper is a Belgian molecular biologist and professor at VIB and KU Leuven (Leuven, Belgium) and the UK Dementia Research Institute and University College London, UK. His research interests are in Alzheimer's and other neurodegenerative diseases.

Research and Career

De Strooper obtained an MD at the Katholieke Universiteit Leuven in 1985 and a PhD in 1992. He did a Postdoc at the EMBL in Heidelberg Germany in 1994. He has been VIB Group leader since 1999, and was Scientific Director, from 2007 to 2016, of the VIB Center for the Biology of Disease at KU Leuven (now VIB-KU Leuven Center for Brain & Disease Research).

In December 2016 he became the director of the UK Dementia Research Institute at University College London.[1] The institute, which has funding of £250m, was announced in May 2016.[2]

His research interest are the secretases, proteases which cleave the amyloid precursor protein (APP), resulting in amyloid peptides. The amyloid peptide is the main constituent of the plaques in the brain of people with Alzheimer's Disease.

Awards

Together with Christian Haass he received the Potamkin Prize in 2002.[3]

He shared the 2018 Brain Prize with John Hardy, Christian Haass and Michel Goedert.[4]

References

  1. ↑ "Director announced to lead landmark UK Dementia Research Institute". Alzheimer's society. 14 December 2016. Retrieved 14 December 2016.
  2. ↑ Department for Business, Innovation & Skills, Medical Research Council and Jo Johnson MP (1 May 2016). "Charities' historic pledge sees funding for landmark Dementia Research Institute soar to £250 million".
  3. ↑ American Academy of Neurology. "2002 Potamkin prize recognizes the ground-breaking work of Alzheimer's disease researchers in Germany, Belgium".
  4. ↑ "Home - Lundbeckfonden - The Brain Prize". www.thebrainprize.org. Retrieved 2018-07-29.
  • De Strooper, B.; Saftig, P.; Craessaerts, K.; Vanderstichele, H.; Guhde, G.; Annaert, W.; von Figura, K.; Van Leuven, F. (1998). "Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein". Nature. 391 (6665): 387–90. doi:10.1038/34910. PMID 9450754.
  • De Strooper, B.; Kopan, R.; Annaert, W.; Cupers, P.; Saftig, P.; Craessaerts, K.; Mumm, J. S.; Schroeter, E. H.; Schrijvers, V.; Wolfe, M. S.; Ray, W. J.; Goate, A. (1999). "A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain". Nature. 398 (6727): 518–22. doi:10.1038/19083. PMID 10206645.

Sources

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