Bag-1 internal ribosome entry site (IRES)

Bag-1 internal ribosome entry site (IRES)
	Predicted secondary structure and sequence conservation of IRES_Bag1
Identifiers
Symbol	IRES_Bag1
Alt. Symbols	Bag1_IRES
Rfam	RF00222
Other data
RNA type	Cis-reg; IRES
Domain(s)	Eukaryota
GO	0043022
SO	0000243
PDB structures	PDBe

The bag-1 internal ribosome entry site (IRES) is a cis-acting element located in the 5 ' untranslated region of the BAG-1 protein mRNA. Its effects apoptosis through IRES mediated translation of the BAG-1 protein.^[1]

When expressed, the BAG-1 protein is known to enhance the anti-apoptotic properties of the Bcl-2 protein. Although bag-1 translation usually occurs via a cap-dependent mechanism it has been found to contain an IRES in its 5' UTR. Translation via the IRES has been found to be common following heat shock when cap-dependent scanning is compromised.^[1]

References

1 2 Coldwell MJ, deSchoolmeester ML, Fraser GA, Pickering BM, Packham G, Willis AE (2001). "The p36 isoform of BAG-1 is translated by internal ribosome entry following heat shock". Oncogene. 20 (30): 4095–100. doi:10.1038/sj.onc.1204547. PMID 11494137.

External links

Page for Bag-1 internal ribosome entry site (IRES) at Rfam

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[pmid11494137-1] 1 2 Coldwell MJ, deSchoolmeester ML, Fraser GA, Pickering BM, Packham G, Willis AE (2001). "The p36 isoform of BAG-1 is translated by internal ribosome entry following heat shock". Oncogene. 20 (30): 4095–100. doi:10.1038/sj.onc.1204547. PMID 11494137.