BTF3

BTF3
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesBTF3, BETA-NAC, BTF3a, BTF3b, NACB, basic transcription factor 3
External IDsMGI: 1202875 HomoloGene: 37453 GeneCards: BTF3
Gene location (Human)
Chr.Chromosome 5 (human)[1]
Band5q13.2Start73,498,408 bp[1]
End73,505,635 bp[1]
Orthologs
SpeciesHumanMouse
Entrez

689

218490

Ensembl

ENSG00000145741

ENSMUSG00000021660

UniProt

P20290

Q64152

RefSeq (mRNA)

NM_001207
NM_001037637

NM_001170540
NM_145455

RefSeq (protein)

NP_001032726
NP_001198

NP_001164011
NP_663430

Location (UCSC)Chr 5: 73.5 – 73.51 MbChr 13: 98.31 – 98.32 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Transcription factor BTF3 is a protein that in humans is encoded by the BTF3 gene.[5][6][7][8]

Function

This gene encodes the basic transcription factor 3. This protein forms a stable complex with RNA polymerase IIB and is required for transcriptional initiation. Alternative splicing results in multiple transcript variants encoding different isoforms. This gene has multiple pseudogenes.[8]

Interactions

BTF3 has been shown to interact with CSNK2B.[9]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000145741 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000021660 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:".
  4. ↑ "Mouse PubMed Reference:".
  5. ↑ Zheng XM, Black D, Chambon P, Egly JM (May 1990). "Sequencing and expression of complementary DNA for the general transcription factor BTF3". Nature. 344 (6266): 556–9. doi:10.1038/344556a0. PMID 2320128.
  6. ↑ Kanno M, Chalut C, Egly JM (Sep 1992). "Genomic structure of the putative BTF3 transcription factor". Gene. 117 (2): 219–28. doi:10.1016/0378-1119(92)90732-5. PMID 1386332.
  7. ↑ Freire MA (Apr 2005). "Translation initiation factor (iso) 4E interacts with BTF3, the beta subunit of the nascent polypeptide-associated complex". Gene. 345 (2): 271–7. doi:10.1016/j.gene.2004.11.030. PMID 15716105.
  8. 1 2 "Entrez Gene: BTF3 basic transcription factor 3".
  9. ↑ Grein S, Pyerin W (Jan 1999). "BTF3 is a potential new substrate of protein kinase CK2". Mol. Cell. Biochem. 191 (1–2): 121–8. doi:10.1023/A:1006806226764. PMID 10094400.

Further reading

  • Wiedmann B, Sakai H, Davis TA, Wiedmann M (1994). "A protein complex required for signal-sequence-specific sorting and translocation". Nature. 370 (6489): 434–40. doi:10.1038/370434a0. PMID 8047162.
  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
  • Grein S, Pyerin W (1999). "BTF3 is a potential new substrate of protein kinase CK2". Mol. Cell. Biochem. 191 (1–2): 121–8. doi:10.1023/A:1006806226764. PMID 10094400.
  • Harrington JJ, Sherf B, Rundlett S, Jackson PD, Perry R, Cain S, Leventhal C, Thornton M, Ramachandran R, Whittington J, Lerner L, Costanzo D, McElligott K, Boozer S, Mays R, Smith E, Veloso N, Klika A, Hess J, Cothren K, Lo K, Offenbacher J, Danzig J, Ducar M (2001). "Creation of genome-wide protein expression libraries using random activation of gene expression". Nat. Biotechnol. 19 (5): 440–5. doi:10.1038/88107. PMID 11329013.
  • Kusumawidjaja G, Kayed H, Giese N, Bauer A, Erkan M, Giese T, Hoheise JD, Friess H, Kleeff J (2007). "Basic transcription factor 3 (BTF3) regulates transcription of tumor-associated genes in pancreatic cancer cells". Cancer Biol. Ther. 6 (3): 367–76. doi:10.4161/cbt.6.3.3704. PMID 17312387.
  • Symes AJ, Eilertsen M, Millar M, Nariculam J, Freeman A, Notara M, Feneley MR, Patel HR, Patel HR, Masters JR, Ahmed A (2013). "Quantitative Analysis of BTF3, HINT1, NDRG1 and ODC1 Protein Over-Expression in Human Prostate Cancer Tissue". PLoS ONE. 8 (12): e84295. doi:10.1371/journal.pone.0084295. PMC 3874000. PMID 24386364.


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