BSTFA

BSTFA
Names
	IUPAC name trimethylsilyl 2,2,2-trifluoro-N-trimethylsilylethanimidate
	Other names BSTFA, N,O-Bis(trimethylsilyl)trifluoroacetamide
Identifiers
CAS Number	25561-30-2 ;
3D model (JSmol)	Interactive image;
ChEBI	CHEBI:85067 ;
ChemSpider	4518443 ;
ECHA InfoCard	100.042.807
PubChem CID	94358;
	InChI InChI=1S/C8H18F3NOSi2/c1-14(2,3)12-7(8(9,10)11)13-15(4,5)6/h1-6H3/b12-7+ Key: XCOBLONWWXQEBS-KPKJPENVSA-N ; InChI=1/C8H18F3NOSi2/c1-14(2,3)12-7(8(9,10)11)13-15(4,5)6/h1-6H3/b12-7+ Key: XCOBLONWWXQEBS-KPKJPENVBV;
	SMILES C[Si](C)(C)O\C(\C(F)(F)F)=N\[Si](C)(C)C;
Properties
Chemical formula	C8H18F3NOSi2
Molar mass	257.40 g·mol−1
Appearance	colourless
Density	0.96
Melting point	−10 °C (14 °F; 263 K)
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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	Infobox references

N,O-Bis(trimethylsilyl)trifluoroacetamide (BSTFA) is a chemical compound that is used to derivatise labile groups such as hydroxyl on other chemicals, with the more stable trimethylsilyl group, which protects the labile group and allows the compound to be used for analytical purposes or as a chemical reagent for synthesis of more complex molecules.^[1] Siloxanes are usually more volatile than the corresponding hydroxyl compounds, and thus can be analyzed with gas chromatography better than the parent compound.

References

↑ Stalling DL, Gehrke CW, Zumwalt RW. A new silylation reagent for amino acids bis(trimethylsilyl)trifluoroacetamide (BSTFA). Biochemical and Biophysical Research Communications. 1968 May 23;31(4):616-22. PMID 5656249

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[1] Stalling DL, Gehrke CW, Zumwalt RW. A new silylation reagent for amino acids bis(trimethylsilyl)trifluoroacetamide (BSTFA). Biochemical and Biophysical Research Communications. 1968 May 23;31(4):616-22. PMID 5656249