Azim Surani

Azim Surani
CBE FRS FMedSci
Born 1945 (age 72–73)
Kisumu, Kenya
Alma mater Plymouth University (BSc)
University of Strathclyde (MSc)
University of Cambridge (PhD)
Awards Gabor Medal (2001)
Royal Medal (2010)
Mendel Lectures (2010)
Gairdner Foundation International Award (2018)[1]
Scientific career
Institutions University of Cambridge
Thesis Modulation of Implanting Rat Blastocysts to Macromolecular Secretions of the Uterus (1975)
Doctoral advisor Robert Edwards
Doctoral students Kat Arney[2]
Other notable students Anne Ferguson-Smith (postdoc)[3]
Website www.gurdon.cam.ac.uk/research/surani

Azim Surani CBE FRS FMedSci[1] (born 1945 in Kisumu, Kenya) is a developmental biologist who has been Marshall–Walton Professor at the Wellcome Trust/Cancer Research UK Gurdon Institute at the University of Cambridge since 1992, and Director of Germline and Epigenomics Research since 2013.[4][5]

Education

Azim was educated at the Plymouth University (BSc), the University of Strathclyde (MSc)[6] and the University of Cambridge (PhD) where his research was supervised by the Nobel laureate Robert Edwards.[6][7][1]

Career and research

Surani discovered mammalian genomic imprinting in 1984, and subsequently examined its mechanism and the functions of imprinted genes.[1] He later established the genetic basis for germ cell specification, using a single-cell analysis in mice.[1] This genetic network also initiates the unique resetting of the germline epigenome, including comprehensive erasure of DNA methylation towards re-establishing full genomic potency.[1] Epigenetic modifications and re-establishments of imprints then generate functional differences between parental genomes whilst aberrant imprints contribute to human disease.[1]

Surani's research is identifying key regulators of human germ line development and epigenome reprogramming, revealing differences between humans and mice attributable to their divergent pluripotent states and early postimplantation development.[1] He is also investigating transposable elements, host defence mechanisms, noncoding RNAs, and the potential for transgenerational epigenetic inheritance in mammals.[1]

Awards and honours

Surani has received several awards for his work including the Royal Medal (2010), the Gabor Medal (2001) and the Mendel Lectures (2010).

References

  1. 1 2 3 4 5 6 7 8 9 Anon (1990). "Professor Azim Surani". royalsociety.org. London: Royal Society. Archived from the original on 2015-11-17. One or more of the preceding sentences incorporates text from the royalsociety.org website where:
    “All text published under the heading 'Biography' on Fellow profile pages is available under Creative Commons Attribution 4.0 International License.” --Royal Society Terms, conditions and policies at the Wayback Machine (archived 2016-11-11)
  2. ↑ Arney, Katharine Luisa (2002). Epigenetic modification in the mouse zygote and regulation of imprinted genes (PhD thesis). University of Cambridge. OCLC 894595629.
  3. ↑ Ferguson-Smith, A. C.; Cattanach, B. M.; Barton, S. C.; Beechey, C. V.; Surani, M. A. (1991). "Embryological and molecular investigations of parental imprinting on mouse chromosome 7". Nature. 351 (6328): 667–670. doi:10.1038/351667a0. ISSN 0028-0836. PMID 2052093.
  4. ↑ Azim Surani publications indexed by the Scopus bibliographic database. (subscription required)
  5. ↑ "Azim Surani — The Gurdon Institute". Gurdon.cam.ac.uk. Retrieved 29 August 2017.
  6. 1 2 McFarlane, Alan (2009). "Azim Surani interviewed by Alan Macfarlane". alanmacfarlane.com. Archived from the original on 2016-03-06.
  7. ↑ Surani, M. A. H. (1975). Modulation of Implanting Rat Blastocysts to Macromolecular Secretions of the Uterus. ethos.bl.uk (PhD thesis). University of Cambridge. OCLC 500574338.


This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.