AsponA antisense RNA

AsponA antisense RNA
Predicted secondary structure and sequence conservation of AsponA antisense RNA
Identifiers
Rfam RF02812
Other data
Domain(s) Bacteria
GO 0046677
SO 0000077,0000370
PDB structures PDBe

AsponA is a small asRNA transcribed antisense to the penicillin-binding protein 1A gene called ponA. It was identified by RNAseq and the expression was validated by 5' and 3' RACE experiments in Pseudomanas aeruginosa. AsponA expression was up or down regulated under different antibiotic stress. Due to it s location it may be able to prevent the transcription or translation of the opposite gene.[1] Study by Wurtzel et al. and Ferrara et al. also detected its expression.[2][3]

See also

References

  1. ↑ Gómez-Lozano, María; Marvig, Rasmus L.; Tulstrup, Monica V. L.; Molin, Søren (2014-09-11). "Expression of antisense small RNAs in response to stress in Pseudomonas aeruginosa". BMC Genomics. 15: 783. doi:10.1186/1471-2164-15-783. ISSN 1471-2164. PMC 4180829. PMID 25213728.
  2. ↑ Wurtzel, Omri; Yoder-Himes, Deborah R.; Han, Kook; Dandekar, Ajai A.; Edelheit, Sarit; Greenberg, E. Peter; Sorek, Rotem; Lory, Stephen (September 2012). "The single-nucleotide resolution transcriptome of Pseudomonas aeruginosa grown in body temperature". PLoS Pathogens. 8 (9): e1002945. doi:10.1371/journal.ppat.1002945. ISSN 1553-7374. PMC 3460626. PMID 23028334.
  3. ↑ Ferrara, Silvia; Brugnoli, Margherita; De Bonis, Angela; Righetti, Francesco; Delvillani, Francesco; Dehò, Gianni; Horner, David; Briani, Federica; Bertoni, Giovanni (2012). "Comparative profiling of Pseudomonas aeruginosa strains reveals differential expression of novel unique and conserved small RNAs". PLOS One. 7 (5): e36553. doi:10.1371/journal.pone.0036553. ISSN 1932-6203. PMC 3349714. PMID 22590564.
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