Anti small RNA

Anti GcvB sRNA
Predicted secondary structure and sequence conservation Anti GcvB sRNA
Identifiers
Rfam RF02702
Other data
Domain(s) Bacteria
GO 0045975
SO 0000370
PDB structures PDBe
Anti stx2 sRNA
Predicted secondary structure and sequence conservation Anti stx2 sRNA
Identifiers
Rfam RF02703
Other data
Domain(s) Bacteria
GO 0045975
SO 0000370
PDB structures PDBe

In bacteria small RNAs play a major role as a regulators of mRNA translation and stability. It was shown in a study using the enterohemorrhagic E. coli that unusually short (between 50 and 60 nucleotide long) small RNAs are expressed by bacteriophages and bacteriophage-derived pathogenicity islands. They modulate the activities of bacterial host small RNAs. AsxR sRNA acts to increase expression of the ChuS heme oxygenase via destabilisation of FnrS sRNA and AgvB sRNA inhibits GcvB sRNA repression.[1][2]

References

  1. ↑ Tree, Jai J.; Granneman, Sander; McAteer, Sean P.; Tollervey, David; Gally, David L. (2014-07-17). "Identification of bacteriophage-encoded anti-sRNAs in pathogenic Escherichia coli". Molecular Cell. 55 (2): 199–213. doi:10.1016/j.molcel.2014.05.006. PMC 4104026. PMID 24910100.
  2. ↑ Bhatt, Shantanu; Egan, Marisa; Jenkins, Valerie; Muche, Sarah; El-Fenej, Jihad (2016). "The Tip of the Iceberg: On the Roles of Regulatory Small RNAs in the Virulence of Enterohemorrhagic and Enteropathogenic Escherichia coli". Frontiers in Cellular and Infection Microbiology. 6: 105. doi:10.3389/fcimb.2016.00105. ISSN 2235-2988. PMC 5030294. PMID 27709103.


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