Anthony Zador

Anthony Zador
Nationality American
Education B.A., University of California, Berkeley; MD-PhD, Yale University
Known for Molecular approaches to connectomics; neural circuits underlying auditory decision making
Scientific career
Fields Neuroscience
Institutions Cold Spring Harbor Laboratory
Doctoral advisor Christof Koch
Other academic advisors Charles F. Stevens

Anthony M. Zador is an American neuroscientist and the Alle Davis Harris Professor of Biology and Chair of Neuroscience at Cold Spring Harbor Laboratory.[1] He is a co-founder of the Computational and Systems Neuroscience (COSYNE) conference. Dr. Zador's research has focused on understanding the circuits of the auditory cortex in rodents. More recently, he proposed a new approach to connectome mapping using the methods of molecular biology, which may dramatically decrease the cost and improve the speed of mapping neuronal circuits at the single cell level.[2][3]

Biography

Anthony Zador received a B.A. at the UC, Berkeley and MD/PhD from Yale University, under the supervision of Tom Brown and Christof Koch at Caltech. He carried out postdoctoral research at the Salk Institute with Chuck Stevens before assuming a faculty position at Cold Spring Harbor Laboratory.

At CSHL, together with Zachary Mainen, he pioneered the use of quantitative behavioral paradigms in rodents to study perception and cognition.[4] In 2012, Dr. Zador proposed a method harnessing advances in DNA sequencing to map neural circuits with much higher throughput than conventional microscopy-based approaches.[5] This method promises to reconstruct the connectivity matrices of entire brains with single cell resolution. So far, a variant of this approach has been applied to map the projection patterns single locus coeruleus neurons at the mesoscale.[3][6]

Zador was recognized as a 2015 Foreign Policy Global Thinker.[7] He is also an occasional columnist for the Observer, writing on the intersection of science, technology and policy.[8]

References

  1. ↑ "CSHL Anthony Zador". Cold Spring Harbor Laboratory. Retrieved 14 December 2016.
  2. ↑ "Sequencing the Connectome: Will DNA Bar Codes and a Sneaky Virus Change the Way Scientists Map the Brain?". Scientific American. 23 October 2012. Retrieved 14 December 2016.
  3. 1 2 "Mapmaking with barcoded neurons". Nature Methods. 31 October 2016. Retrieved 14 December 2016.
  4. ↑ "Neuroscience: The rat pack". Nature. 19 May 2010. Retrieved 14 December 2016.
  5. ↑ Zador AM, Dubnau J, Oyibo HK, Zhan H, Cao G, Peikon ID (2012). "Sequencing the Connectome". PLOS Biology. doi:10.1371/journal.pbio.1001411.
  6. ↑ Kebschull JM, Garcia da Silva P, Reid AP, Peikon ID, Albeanu DF, Zador AM (2016). "High-Throughput Mapping of Single-Neuron Projections by Sequencing of Barcoded RNA". Neuron. 91 (5): 975–87. doi:10.1016/j.neuron.2016.07.036.
  7. ↑ "The Year of Changing Our Minds: The Leading Global Thinkers of 2015". Foreign Policy.
  8. ↑ "Government's 'Golden Fleece' Is Now Humanity's Golden Goose".
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