Andrew P. Carter

Andrew P Carter
Nationality British
Alma mater
Awards EMBO Member (2016)
Scientific career
Fields
Institutions
Doctoral advisor Venki Ramakrishnan
Other academic advisors Ron Vale
Website www2.mrc-lmb.cam.ac.uk/groups/cartera/

Andrew P. Carter is a British structural biologist who works at the Medical Research Council (MRC) Laboratory of Molecular Biology (LMB) in Cambridge, UK. He is known for his work on the microtubule motor dynein[1][2][3][4].

Education

Carter studied Biochemistry at the University of Oxford, graduating in 1999[5]. He obtained a PhD in 2003 from the MRC Laboratory of Molecular Biology where he worked with Venki Ramakrishnan on the ribosome. He was a member of the team in Ramakrishnan's lab that solved the first X-ray crystal structure of the small (30S) ribosomal subunit[6]. Carter also determined structures of 30S bound to antibiotics[7] and bound to the initiation factor IF1[8]. Ramakrishnan shared the Nobel prize in Chemistry for the team's work on the 30S[9].

Career and research

Carter was a post-doc in Ron Vale's lab[10] at University of California, San Francisco from 2003 to 2010. During his post-doc, he studied the molecular motor protein, dynein using X-ray crystallography and single molecule fluorescence microscopy[11][12].

He became a group leader at MRC Laboratory of Molecular Biology in Cambridge in 2010 where he uses X-ray crystallography, electron microscopy, and single molecule microscopy assays to understand how dynein transports cargo. His group solved X-ray crystal structures of the dynein motor domain showing how it generates force to pull cargos along microtubules[1] and reconstituted a recombinant dynein, showing how its processive movement is activated by cofactors/cargo adaptors[13]. His group used cryoEM to solve the structure of dynein's cofactor dynactin[2] and the full length dynein complex[3].  They showed how dynein and dynactin come together in the presence of cargos and how this activates transport.

Grants, awards and honours

References

  1. 1 2 Schmidt, Helgo; Zalyte, Ruta; Urnavicius, Linas; Carter, Andrew P. (2015-02-19). "Structure of human cytoplasmic dynein-2 primed for its power stroke". Nature. 518 (7539): 435–438. doi:10.1038/nature14023. ISSN 1476-4687. PMC 4336856. PMID 25470043.
  2. 1 2 Urnavicius, Linas; Zhang, Kai; Diamant, Aristides G.; Motz, Carina; Schlager, Max A.; Yu, Minmin; Patel, Nisha A.; Robinson, Carol V.; Carter, Andrew P. (2015-03-27). "The structure of the dynactin complex and its interaction with dynein". Science. 347 (6229): 1441–1446. doi:10.1126/science.aaa4080. ISSN 1095-9203. PMC 4413427. PMID 25814576.
  3. 1 2 Zhang, Kai; Foster, Helen E.; Rondelet, Arnaud; Lacey, Samuel E.; Bahi-Buisson, Nadia; Bird, Alexander W.; Carter, Andrew P. (2017-06-15). "Cryo-EM Reveals How Human Cytoplasmic Dynein Is Auto-inhibited and Activated". Cell. 169 (7): 1303–1314.e18. doi:10.1016/j.cell.2017.05.025. ISSN 1097-4172. PMC 5473941. PMID 28602352.
  4. ↑ Urnavicius, Linas; Lau, Clinton K.; Elshenawy, Mohamed M.; Morales-Rios, Edgar; Motz, Carina; Yildiz, Ahmet; Carter, Andrew P. (2018-02-07). "Cryo-EM shows how dynactin recruits two dyneins for faster movement". Nature. 554 (7691): 202–206. doi:10.1038/nature25462. ISSN 1476-4687. PMC 5988349. PMID 29420470.
  5. ↑ "2012 Alumni Lecture celebrating Oxford Biochemistry graduate success Page - Department of Biochemistry, University of Oxford". www.bioch.ox.ac.uk. Retrieved 2018-08-26.
  6. ↑ Wimberly, B. T.; Brodersen, D. E.; Clemons, W. M.; Morgan-Warren, R. J.; Carter, A. P.; Vonrhein, C.; Hartsch, T.; Ramakrishnan, V. (2000-09-21). "Structure of the 30S ribosomal subunit". Nature. 407 (6802): 327–339. doi:10.1038/35030006. ISSN 0028-0836. PMID 11014182.
  7. ↑ Carter, A. P.; Clemons, W. M.; Brodersen, D. E.; Morgan-Warren, R. J.; Wimberly, B. T.; Ramakrishnan, V. (2000-09-21). "Functional insights from the structure of the 30S ribosomal subunit and its interactions with antibiotics". Nature. 407 (6802): 340–348. doi:10.1038/35030019. ISSN 0028-0836. PMID 11014183.
  8. ↑ Carter, A. P.; Clemons, W. M.; Brodersen, D. E.; Morgan-Warren, R. J.; Hartsch, T.; Wimberly, B. T.; Ramakrishnan, V. (2001-01-19). "Crystal structure of an initiation factor bound to the 30S ribosomal subunit". Science. 291 (5503): 498–501. ISSN 0036-8075. PMID 11228145.
  9. ↑ "Venkatraman Ramakrishnan - Nobel Lecture: Unraveling the Structure of the Ribosome". NobelPrize.org. Retrieved 2018-08-26.
  10. ↑ "Carter". valelab.ucsf.edu. Retrieved 2018-08-25.
  11. ↑ Carter, Andrew P.; Garbarino, Joan E.; Wilson-Kubalek, Elizabeth M.; Shipley, Wesley E.; Cho, Carol; Milligan, Ronald A.; Vale, Ronald D.; Gibbons, I. R. (2008-12-12). "Structure and functional role of dynein's microtubule-binding domain". Science. 322 (5908): 1691–1695. doi:10.1126/science.1164424. ISSN 1095-9203. PMC 2663340. PMID 19074350.
  12. ↑ Carter, Andrew P.; Cho, Carol; Jin, Lan; Vale, Ronald D. (2011-03-04). "Crystal structure of the dynein motor domain". Science. 331 (6021): 1159–1165. doi:10.1126/science.1202393. ISSN 1095-9203. PMC 3169322. PMID 21330489.
  13. ↑ Schlager, Max A.; Hoang, Ha Thi; Urnavicius, Linas; Bullock, Simon L.; Carter, Andrew P. (2014-09-01). "In vitro reconstitution of a highly processive recombinant human dynein complex". The EMBO Journal. 33 (17): 1855–1868. doi:10.15252/embj.201488792. ISSN 1460-2075. PMC 4158905. PMID 24986880.
  14. ↑ "LMB Student Prize - MRC Laboratory of Molecular Biology". MRC Laboratory of Molecular Biology. Retrieved 2018-08-26.
  15. ↑ "Agouron Institute | Fellowships". agi.org. Retrieved 2018-08-26.
  16. ↑ Cambridge, Clare College. "Dr Andrew Carter - Clare College Cambridge". www.clare.cam.ac.uk. Retrieved 2018-08-25.
  17. ↑ adit. "22 young group leaders recognized as EMBO Young Investigators". EMBO. Retrieved 2018-08-26.
  18. 1 2 "Investigator Awards in Science: people we've funded | Wellcome". wellcome.ac.uk. Retrieved 2018-08-26.
  19. ↑ "Find people in the EMBO Communities". people.embo.org. Retrieved 2018-08-26.
  20. ↑ User, Super. "58 life science researchers elected as new EMBO Members". EMBO. Retrieved 2018-08-26.
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