ATP5H

ATP5PD
Identifiers
AliasesATP5PD, ATPQ, ATP synthase, H+ transporting, mitochondrial Fo complex subunit D, ATP5H, ATP synthase peripheral stalk subunit d
External IDsMGI: 1918929 HomoloGene: 130552 GeneCards: ATP5PD
Gene location (Human)
Chr.Chromosome 17 (human)[1]
Band17q25.1Start75,038,863 bp[1]
End75,046,985 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

10476

71679

Ensembl

ENSG00000167863

ENSMUSG00000034566

UniProt

O75947

Q9DCX2

RefSeq (mRNA)

NM_006356
NM_001003785

NM_027862

RefSeq (protein)

NP_001003785
NP_006347

NP_082138

Location (UCSC)Chr 17: 75.04 – 75.05 MbChr 11: 115.42 – 115.42 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse
ATP synthase D chain, mitochondrial
Identifiers
Symbol ATP5H
Pfam PF05873

The human gene ATP5H encodes subunit d of the enzyme mitochondrial ATP synthase.[5][6]

Mitochondrial ATP synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. It is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, F0, which comprises the proton channel. The F1 complex consists of 5 different subunits (alpha, beta, gamma, delta, and epsilon) assembled in a ratio of 3 alpha, 3 beta, and a single representative of the other 3. The F0 seems to have nine subunits (a, b, c, d, e, f, g, F6 and 8). This gene encodes the d subunit of the F0 complex. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. In addition, three pseudogenes are located on chromosomes 9, 12 and 15.[6]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000167863 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000034566 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:".
  4. ↑ "Mouse PubMed Reference:".
  5. ↑ Zhang QH, Ye M, Wu XY, Ren SX, Zhao M, Zhao CJ, Fu G, Shen Y, Fan HY, Lu G, Zhong M, Xu XR, Han ZG, Zhang JW, Tao J, Huang QH, Zhou J, Hu GX, Gu J, Chen SJ, Chen Z (Nov 2000). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells". Genome Res. 10 (10): 1546–60. doi:10.1101/gr.140200. PMC 310934. PMID 11042152.
  6. 1 2 "Entrez Gene: ATP5H ATP synthase, H+ transporting, mitochondrial F0 complex, subunit d".

Further reading

  • Kinosita K, Yasuda R, Noji H (2003). "F1-ATPase: a highly efficient rotary ATP machine". Essays Biochem. 35: 3–18. PMID 12471886.
  • Oster G, Wang H (2003). "Rotary protein motors". Trends Cell Biol. 13 (3): 114–21. doi:10.1016/S0962-8924(03)00004-7. PMID 12628343.
  • Leyva JA, Bianchet MA, Amzel LM (2003). "Understanding ATP synthesis: structure and mechanism of the F1-ATPase (Review)". Mol. Membr. Biol. 20 (1): 27–33. doi:10.1080/0968768031000066532. PMID 12745923.
  • Higuti T, Kuroiwa K, Miyazaki S, et al. (1994). "The complete amino acid sequence of subunit d of rat liver mitochondrial H(+)-ATP synthase". J. Biochem. 114 (5): 714–7. PMID 7509337.
  • Elston T, Wang H, Oster G (1998). "Energy transduction in ATP synthase". Nature. 391 (6666): 510–3. doi:10.1038/35185. PMID 9461222.
  • Wang H, Oster G (1998). "Energy transduction in the F1 motor of ATP synthase". Nature. 396 (6708): 279–82. doi:10.1038/24409. PMID 9834036.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Cross RL (2004). "Molecular motors: turning the ATP motor". Nature. 427 (6973): 407–8. doi:10.1038/427407b. PMID 14749816.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.


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