ATG4D

ATG4D
Identifiers
AliasesATG4D, APG4-D, APG4D, AUTL4, autophagy related 4D cysteine peptidase
External IDsMGI: 2444308 HomoloGene: 13156 GeneCards: ATG4D
Gene location (Human)
Chr.Chromosome 19 (human)[1]
Band19p13.2Start10,543,895 bp[1]
End10,553,418 bp[1]
Orthologs
SpeciesHumanMouse
Entrez

84971

235040

Ensembl

ENSG00000130734

ENSMUSG00000002820

UniProt

Q86TL0

Q8BGV9

RefSeq (mRNA)

NM_001281504
NM_032885

NM_153583

RefSeq (protein)

NP_001268433
NP_116274

NP_705811

Location (UCSC)Chr 19: 10.54 – 10.55 MbChr 9: 21.27 – 21.28 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

The human ATG4D gene encodes the protein Autophagy related 4D, cysteine peptidase.[5]

Function

Autophagy is the process by which endogenous proteins and damaged organelles are destroyed intracellularly. Autophagy is postulated to be essential for cell homeostasis and cell remodeling during differentiation, metamorphosis, non-apoptotic cell death, and aging. Reduced levels of autophagy have been described in some malignant tumors, and a role for autophagy in controlling the unregulated cell growth linked to cancer has been proposed.

This gene belongs to the autophagy-related protein 4 (Atg4) family of C54 endopeptidases. Members of this family encode proteins that play a role in the biogenesis of autophagosomes, which sequester the cytosol and organelles for degradation by lysosomes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013].

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000130734 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000002820 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:".
  4. ↑ "Mouse PubMed Reference:".
  5. ↑ "Entrez Gene: Autophagy related 4D, cysteine peptidase".

Further reading

  • Betin VM, MacVicar TD, Parsons SF, Anstee DJ, Lane JD (April 2012). "A cryptic mitochondrial targeting motif in Atg4D links caspase cleavage with mitochondrial import and oxidative stress". Autophagy. 8 (4): 664–76. doi:10.4161/auto.19227. PMC 3405841. PMID 22441018.
  • Betin VM, Lane JD (July 2009). "Caspase cleavage of Atg4D stimulates GABARAP-L1 processing and triggers mitochondrial targeting and apoptosis". Journal of Cell Science. 122 (Pt 14): 2554–66. doi:10.1242/jcs.046250. PMC 2704886. PMID 19549685.
  • Mariño G, Uría JA, Puente XS, Quesada V, Bordallo J, López-Otín C (February 2003). "Human autophagins, a family of cysteine proteinases potentially implicated in cell degradation by autophagy". The Journal of Biological Chemistry. 278 (6): 3671–8. doi:10.1074/jbc.M208247200. PMID 12446702.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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